![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Research Papers
Laboratory of Molecular Genetics, Faculty of Science, Kyushu University, Fukuoka, Japan.
Abstract
The human RCC1 gene was cloned after DNA-mediated gene transfer into the tsBN2 cell line, which shows premature chromosome condensation at nonpermissive temperatures (39.5-40 degrees C). This gene codes for a 2.5-kb poly(A)+ RNA that is well conserved in hamsters and humans. We isolated 15 cDNA clones from the Okayama-Berg human cDNA library, and found two that can complement the tsBN2 mutation with an efficiency comparable to that of the genomic DNA clone. The base sequences of these two active cDNA clones differ at the 5' proximal end, yet both have a common open reading frame, encoding a protein of 421 amino acids with a calculated molecular weight of 44,847 and with seven homologous repeated domains of about 60 amino acids. This human RCC1 gene was located to human chromosome 1 using sorted chromosomal fractions.
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  M. J. Winton, L. M. Igaz, M. M. Wong, L. K. Kwong, J. Q. Trojanowski, and V. M.-Y. Lee Disturbance of Nuclear and Cytoplasmic TAR DNA-binding Protein (TDP-43) Induces Disease-like Redistribution, Sequestration, and Aggregate Formation J. Biol. Chem., May 9, 2008; 283(19): 13302 - 13309. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. L. Strang and N. D. Stow Blocks to herpes simplex virus type 1 replication in a cell line, tsBN2, encoding a temperature-sensitive RCC1 protein J. Gen. Virol., February 1, 2007; 88(2): 376 - 383. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Hadano, S. C. Benn, S. Kakuta, A. Otomo, K. Sudo, R. Kunita, K. Suzuki-Utsunomiya, H. Mizumura, J. M. Shefner, G. A. Cox, et al. Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking Hum. Mol. Genet., January 15, 2006; 15(2): 233 - 250. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Casolari, C. R. Brown, D. A. Drubin, O. J. Rando, and P. A. Silver Developmentally induced changes in transcriptional program alter spatial organization across chromosomes Genes & Dev., May 15, 2005; 19(10): 1188 - 1198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Kunita, A. Otomo, H. Mizumura, K. Suzuki, J. Showguchi-Miyata, Y. Yanagisawa, S. Hadano, and J.-E Ikeda Homo-oligomerization of ALS2 through Its Unique Carboxyl-terminal Regions Is Essential for the ALS2-associated Rab5 Guanine Nucleotide Exchange Activity and Its Regulatory Function on Endosome Trafficking J. Biol. Chem., September 10, 2004; 279(37): 38626 - 38635. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D.-F. Guo, V. Tardif, K. Ghelima, J. S. D. Chan, J. R. Ingelfinger, X. Chen, and I. Chenier A Novel Angiotensin II Type 1 Receptor-associated Protein Induces Cellular Hypertrophy in Rat Vascular Smooth Muscle and Renal Proximal Tubular Cells J. Biol. Chem., May 14, 2004; 279(20): 21109 - 21120. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Wang, T. Jatkoe, Y. Zhang, M. G. Mutch, D. Talantov, J. Jiang, H. L. McLeod, and D. Atkins Gene Expression Profiles and Molecular Markers To Predict Recurrence of Dukes' B Colon Cancer J. Clin. Oncol., May 1, 2004; 22(9): 1564 - 1571. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Yamanaka, C. Vande Velde, E. Eymard-Pierre, E. Bertini, O. Boespflug-Tanguy, and D. W. Cleveland Unstable mutants in the peripheral endosomal membrane component ALS2 cause early-onset motor neuron disease PNAS, December 23, 2003; 100(26): 16041 - 16046. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Otomo, S. Hadano, T. Okada, H. Mizumura, R. Kunita, H. Nishijima, J. Showguchi-Miyata, Y. Yanagisawa, E. Kohiki, E. Suga, et al. ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics Hum. Mol. Genet., July 15, 2003; 12(14): 1671 - 1687. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. M. Loovers, K. Veenstra, H. Snippe, X. Pesesse, C. Erneux, and P. J. M. van Haastert A Diverse Family of Inositol 5-Phosphatases Playing a Role in Growth and Development in Dictyostelium discoideum J. Biol. Chem., February 14, 2003; 278(8): 5652 - 5658. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Harreman, M. R. Hodel, P. Fanara, A. E. Hodel, and A. H. Corbett The Auto-inhibitory Function of Importin alpha Is Essential in Vivo J. Biol. Chem., February 14, 2003; 278(8): 5854 - 5863. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Narayanan, J. Eifert, K. A. Marfatia, I. G. Macara, A. H. Corbett, R. M. Terns, and M. P. Terns Nuclear RanGTP is not required for targeting small nucleolar RNAs to the nucleolus J. Cell Sci., January 1, 2003; 116(1): 177 - 186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Mavlyutov, H. Zhao, and P. A. Ferreira Species-specific subcellular localization of RPGR and RPGRIP isoforms: implications for the phenotypic variability of congenital retinopathies among species Hum. Mol. Genet., August 1, 2002; 11(16): 1899 - 1907. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. B. Deming, C. A. Cistulli, H. Zhao, P. R. Graves, H. Piwnica-Worms, R. S. Paules, C. S. Downes, and W. K. Kaufmann The human decatenation checkpoint PNAS, September 26, 2001; (2001) 221430898. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Mabuchi, H. Fujii, G. Calin, H. Alder, M. Negrini, L. Rassenti, T. J. Kipps, F. Bullrich, and C. M. Croce Cloning and Characterization of CLLD6, CLLD7, and CLLD8, Novel Candidate Genes for Leukemogenesis at Chromosome 13q14, a Region Commonly Deleted in B-Cell Chronic Lymphocytic Leukemia Cancer Res., April 1, 2001; 61(7): 2870 - 2877. [Abstract] [Full Text]
|
|
|
|
 |
|
 Y. Takai, T. Sasaki, and T. Matozaki Small GTP-Binding Proteins Physiol Rev, January 1, 2001; 81(1): 153 - 208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Boylan and A. F. Wright Identification of a novel protein interacting with RPGR Hum. Mol. Genet., September 1, 2000; 9(14): 2085 - 2093. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. B. Quimby, C. A. Wilson, and A. H. Corbett The Interaction Between Ran and NTF2 is Required for Cell Cycle Progression Mol. Biol. Cell, August 1, 2000; 11(8): 2617 - 2629. [Abstract] [Full Text]
|
|
|
|
|
|
S. M. Steggerda, B. E. Black, and B. M. Paschal Monoclonal Antibodies to NTF2 Inhibit Nuclear Protein Import by Preventing Nuclear Translocation of the GTPase Ran Mol. Biol. Cell, February 1, 2000; 11(2): 703 - 719. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. A. Kahana and D. W. Cleveland Beyond Nuclear Transport: Ran-GTP as a Determinant of Spindle Assembly J. Cell Biol., September 20, 1999; 146(6): 1205 - 1210. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kose, N. Imamoto, T. Tachibana, M. Yoshida, and Y. Yoneda beta -Subunit of Nuclear Pore-targeting Complex (Importin-beta ) Can Be Exported from the Nucleus in a Ran-independent Manner J. Biol. Chem., February 12, 1999; 274(7): 3946 - 3952. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Pelczar and W. Filipowicz The Host Gene for Intronic U17 Small Nucleolar RNAs in Mammals Has No Protein-Coding Potential and Is a Member of the 5'-Terminal Oligopyrimidine Gene Family Mol. Cell. Biol., August 1, 1998; 18(8): 4509 - 4518. [Abstract] [Full Text]
|
|
|
|
 |
|
 H. Eggert, K. Bergemann, and H. Saumweber Molecular Screening for P-Element Insertions in a Large Genomic Region of Drosophila melanogaster Using Polymerase Chain Reaction Mediated by the Vectorette Genetics, July 1, 1998; 149(3): 1427 - 1434. [Abstract] [Full Text]
|
|
|
|
|
|
M Hughes, C Zhang, J. Avis, C. Hutchison, and P. Clarke The role of the ran GTPase in nuclear assembly and DNA replication: characterisation of the effects of Ran mutants J. Cell Sci., January 10, 1998; 111(20): 3017 - 3026. [Abstract] [PDF]
|
|
|
|
|
|
E Hirose, N Nakashima, T Sekiguchi, and T Nishimoto RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway J. Cell Sci., January 1, 1998; 111(1): 11 - 21. [Abstract] [PDF]
|
|
|
|
|
|
T. Taura, G. Schlenstedt, and P. A. Silver Yrb2p Is a Nuclear Protein That Interacts with Prp20p, a Yeast Rcc1 Homologue J. Biol. Chem., December 12, 1997; 272(50): 31877 - 31884. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Delphin, T. Guan, F. Melchior, and L. Gerace RanGTP Targets p97 to RanBP2, a Filamentous Protein Localized at the Cytoplasmic Periphery of the Nuclear Pore Complex Mol. Biol. Cell, December 1, 1997; 8(12): 2379 - 2390. [Abstract] [Full Text]
|
|
|
|
|
|
I. Boche and E. Fanning Nucleocytoplasmic Recycling of the Nuclear Localization Signal Receptor alpha Subunit In Vivo Is Dependent on a Nuclear Export Signal, Energy, and RCC1 J. Cell Biol., October 20, 1997; 139(2): 313 - 325. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Floer, G. Blobel, and M. Rexach Disassembly of RanGTP-Karyopherin beta Complex, an Intermediate in Nuclear Protein Import J. Biol. Chem., August 1, 1997; 272(31): 19538 - 19546. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Gorlich, M. Dabrowski, F. R. Bischoff, U. Kutay, P. Bork, E. Hartmann, S. Prehn, and E. Izaurralde A Novel Class of RanGTP Binding Proteins J. Cell Biol., July 14, 1997; 138(1): 65 - 80. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Nicolas, C Zhang, M Hughes, M Goldberg, S Watton, and P Clarke Xenopus Ran-binding protein 1: molecular interactions and effects on nuclear assembly in Xenopus egg extracts J. Cell Sci., January 12, 1997; 110(24): 3019 - 3030. [Abstract] [PDF]
|
|
|
|
|
|
A Battistoni, G Guarguaglini, F Degrassi, C Pittoggi, A Palena, G Di Matteo, C Pisano, E Cundari, and P Lavia Deregulated expression of the RanBP1 gene alters cell cycle progression in murine fibroblasts J. Cell Sci., January 10, 1997; 110(19): 2345 - 2357. [Abstract] [PDF]
|
|
|
|
|
|
H Bastians and H Ponstingl The novel human protein serine/threonine phosphatase 6 is a functional homologue of budding yeast Sit4p and fission yeast ppe1, which are involved in cell cycle regulation J. Cell Sci., January 12, 1996; 109(12): 2865 - 2874. [Abstract] [PDF]
|
|
|
|
|
|
J. Avis and P. Clarke Ran, a GTPase involved in nuclear processes: its regulators and effectors J. Cell Sci., January 10, 1996; 109(10): 2423 - 2427. [Abstract] [PDF]
|
|
|
|
|
|
J Miyabashira, T Sekiguchi, and T Nishimoto Mammalian cells have two functional RCC1 proteins produced by alternative splicing J. Cell Sci., January 8, 1994; 107(8): 2203 - 2208. [Abstract] [PDF]
|
|
|
|
|
|
Q Liu, I Golubovskaya, and W. Cande Abnormal cytoskeletal and chromosome distribution in po, ms4 and ms6; mutant alleles of polymitotic that disrupt the cell cycle progression from meiosis to mitosis in maize J. Cell Sci., January 12, 1993; 106(4): 1169 - 1178. [Abstract] [PDF]
|
|
|
|
|
|
A Lee, R Tam, P Belhumeur, T DiPaolo, and M. Clark Prp20, the Saccharomyces cerevisiae homolog of the regulator of chromosome condensation, RCC1, interacts with double-stranded DNA through a multi-component complex containing GTP-binding proteins J. Cell Sci., January 9, 1993; 106(1): 287 - 298. [Abstract] [PDF]
|
|
|
|
|
|
W Forrester, F Stutz, M Rosbash, and M Wickens Defects in mRNA 3'-end formation, transcription initiation, and mRNA transport associated with the yeast mutation prp20: possible coupling of mRNA processing and chromatin structure. Genes & Dev., October 1, 1992; 6(10): 1914 - 1926. [Abstract] [PDF]
|
|
|
|
|
|
S. M. Steggerda and B. M. Paschal The Mammalian Mog1 Protein Is a Guanine Nucleotide Release Factor for Ran J. Biol. Chem., July 21, 2000; 275(30): 23175 - 23180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. B. Deming, C. A. Cistulli, H. Zhao, P. R. Graves, H. Piwnica-Worms, R. S. Paules, C. S. Downes, and W. K. Kaufmann The human decatenation checkpoint PNAS, October 9, 2001; 98(21): 12044 - 12049. [Abstract] [Full Text] [PDF]
|
|
