![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Research Papers
Department of Biochemistry, University of Washington School of Medicine, Seattle, 98195-7370, USA.
Abstract
The serine/threonine kinase Xgsk-3 and the intracellular protein beta-catenin are necessary for the establishment of the dorsal-ventral axis in Xenopus. Although genetic evidence from Drosophila indicates that Xgsk-3 is upstream of beta-catenin, direct interactions between these proteins have not been demonstrated. We demonstrate that phosphorylation of beta-catenin in vivo requires an in vitro amino-terminal Xgsk-3 phosphorylation site, which is conserved in the Drosophila protein armadillo. beta-catenin mutants lacking this site are more active in inducing an ectopic axis in Xenopus embryos and are more stable than wild-type beta-catenin in the presence of Xgsk-3 activity, supporting the hypothesis that Xgsk-3 is a negative regulator of beta-catenin that acts through the amino-terminal site. Inhibition of endogenous Xgsk-3 function with a dominant-negative mutant leads to an increase in the steady-state levels of ectopic beta-catenin, indicating that Xgsk-3 functions to destabilize beta-catenin and thus decrease the amount of beta-catenin available for signaling. The levels of endogenous beta-catenin in the nucleus increases in the presence of the dominant-negative Xgsk-3 mutant, suggesting that a role of Xgsk-3 is to regulate the steady-state levels of beta-catenin within specific subcellular compartments. These studies provide a basis for understanding the interaction between Xgsk-3 and beta-catenin in the establishment of the dorsal-ventral axis in early Xenopus embryos.
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  B. A. Thompson, V. Tremblay, G. Lin, and D. A. Bochar CHD8 Is an ATP-Dependent Chromatin Remodeling Factor That Regulates {beta}-Catenin Target Genes Mol. Cell. Biol., June 15, 2008; 28(12): 3894 - 3904. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Liu, X. Fang, H. Hall, S. Yu, D. Smith, Z. Lu, D. Fang, J. Liu, L. C. Stephens, J. R. Woodgett, et al. Homozygous deletion of glycogen synthase kinase 3{beta} bypasses senescence allowing Ras transformation of primary murine fibroblasts PNAS, April 1, 2008; 105(13): 5248 - 5253. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Wen, E. Planel, M. Herman, H. Y. Figueroa, L. Wang, L. Liu, L.-F. Lau, W. H. Yu, and K. E. Duff Interplay between Cyclin-Dependent Kinase 5 and Glycogen Synthase Kinase 3{beta} Mediated by Neuregulin Signaling Leads to Differential Effects on Tau Phosphorylation and Amyloid Precursor Protein Processing J. Neurosci., March 5, 2008; 28(10): 2624 - 2632. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P-M Chiang, R-H Yuan, H-C Hsu, T-L Mao, R-H Hu, P-L Lai, and Y-M Jeng Frequent nuclear expression of {beta}-catenin protein but rare {beta}-catenin mutation in pulmonary sclerosing haemangioma J. Clin. Pathol., March 1, 2008; 61(3): 268 - 271. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Merabova, D. Kaniowska, R. Kaminski, S. L. Deshmane, M. K. White, S. Amini, A. Darbinyan, and K. Khalili JC Virus Agnoprotein Inhibits In Vitro Differentiation of Oligodendrocytes and Promotes Apoptosis J. Virol., February 1, 2008; 82(3): 1558 - 1569. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. P. Petersen and P. W. Reddien Smed-{beta}catenin-1 Is Required for Anteroposterior Blastema Polarity in Planarian Regeneration Science, January 18, 2008; 319(5861): 327 - 330. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Shimizu, Y. Fukunaga, J. Ikenouchi, and A. Nagafuchi Defining the Roles of -Catenin and Plakoglobin in LEF/T-Cell Factor-Dependent Transcription Using -Catenin/Plakoglobin-Null F9 Cells Mol. Cell. Biol., January 15, 2008; 28(2): 825 - 835. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Delmas, F. Beermann, S. Martinozzi, S. Carreira, J. Ackermann, M. Kumasaka, L. Denat, J. Goodall, F. Luciani, A. Viros, et al. beta-Catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development Genes & Dev., November 15, 2007; 21(22): 2923 - 2935. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Mishra, M. K. Barthwal, G. Sondarva, B. Rana, L. Wong, M. Chatterjee, J. R. Woodgett, and A. Rana Glycogen Synthase Kinase-3beta Induces Neuronal Cell Death via Direct Phosphorylation of Mixed Lineage Kinase 3 J. Biol. Chem., October 19, 2007; 282(42): 30393 - 30405. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Higgins, P. R. Graves, and L. M. Graves Regulation of Human Cytidine Triphosphate Synthetase 1 by Glycogen Synthase Kinase 3 J. Biol. Chem., October 5, 2007; 282(40): 29493 - 29503. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L. Daugherty and C. J. Gottardi Phospho-regulation of {beta}-Catenin Adhesion and Signaling Functions Physiology, October 1, 2007; 22(5): 303 - 309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Li, Z. Wang, D. Kong, S. Murthy, Q. P. Dou, S. Sheng, G. P. V. Reddy, and F. H. Sarkar Regulation of FOXO3a/beta-Catenin/GSK-3beta Signaling by 3,3'-Diindolylmethane Contributes to Inhibition of Cell Proliferation and Induction of Apoptosis in Prostate Cancer Cells J. Biol. Chem., July 20, 2007; 282(29): 21542 - 21550. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. A. McLin, S. A. Rankin, and A. M. Zorn Repression of Wnt/{beta}-catenin signaling in the anterior endoderm is essential for liver and pancreas development Development, June 15, 2007; 134(12): 2207 - 2217. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Fang, D. Hawke, Y. Zheng, Y. Xia, J. Meisenhelder, H. Nika, G. B. Mills, R. Kobayashi, T. Hunter, and Z. Lu Phosphorylation of beta-Catenin by AKT Promotes beta-Catenin Transcriptional Activity J. Biol. Chem., April 13, 2007; 282(15): 11221 - 11229. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. B. Kim, C. J Lewis, K. D McCall, R. Malgor, A. D Kohn, R. T Moon, and L. D Kohn Overexpression of Wnt-1 in thyrocytes enhances cellular growth but suppresses transcription of the thyroperoxidase gene via different signaling mechanisms J. Endocrinol., April 1, 2007; 193(1): 93 - 106. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Yi and M. D. Ehlers Emerging Roles for Ubiquitin and Protein Degradation in Neuronal Function Pharmacol. Rev., March 1, 2007; 59(1): 14 - 39. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kofron, B. Birsoy, D. Houston, Q. Tao, C. Wylie, and J. Heasman Wnt11/{beta}-catenin signaling in both oocytes and early embryos acts through LRP6-mediated regulation of axin Development, February 1, 2007; 134(3): 503 - 513. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Liu, S. Rajareddy, P. Reddy, K. Jagarlamudi, C. Du, Y. Shen, Y. Guo, K. Boman, E. Lundin, U. Ottander, et al. Phosphorylation and inactivation of glycogen synthase kinase-3 by soluble kit ligand in mouse oocytes during early follicular development J. Mol. Endocrinol., January 1, 2007; 38(1): 137 - 146. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-C. Su, C.-C. Wang, C.-C. Chen, R.-H. Hu, T.-H. Wang, H.-L. Kao, Y.-M. Jeng, and R.-H. Yuan Nuclear Translocation of {beta}-Catenin Protein but Absence of {beta}-Catenin and APC Mutation in Gastrointestinal Carcinoid Tumor Ann. Surg. Oncol., December 1, 2006; 13(12): 1604 - 1609. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Ettensohn The Emergence of Pattern in Embryogenesis: Regulation of beta-Catenin Localization During Early Sea Urchin Development Sci. Signal., November 14, 2006; 2006(361): pe48 - pe48. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Lindsley, J. G. Gill, M. Kyba, T. L. Murphy, and K. M. Murphy Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm Development, October 1, 2006; 133(19): 3787 - 3796. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Zamparini, T. Watts, C. E. Gardner, S. R. Tomlinson, G. I. Johnston, and J. M. Brickman Hex acts with {beta}-catenin to regulate anteroposterior patterning via a Groucho-related co-repressor and Nodal Development, September 15, 2006; 133(18): 3709 - 3722. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Eisinger, L. D. Nadauld, D. N. Shelton, P. W. Peterson, R. A. Phelps, S. Chidester, D. M. Stafforini, S. M. Prescott, and D. A. Jones The Adenomatous Polyposis Coli Tumor Suppressor Gene Regulates Expression of Cyclooxygenase-2 by a Mechanism That Involves Retinoic Acid J. Biol. Chem., July 21, 2006; 281(29): 20474 - 20482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Yaguchi, J. Yaguchi, and R. D. Burke Specification of ectoderm restricts the size of the animal plate and patterns neurogenesis in sea urchin embryos Development, June 15, 2006; 133(12): 2337 - 2346. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Tobimatsu, H. Kaji, H. Sowa, J. Naito, L. Canaff, G. N. Hendy, T. Sugimoto, and K. Chihara Parathyroid Hormone Increases {beta}-Catenin Levels through Smad3 in Mouse Osteoblastic Cells Endocrinology, May 1, 2006; 147(5): 2583 - 2590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-J. Boucher, L. Selander, L. Carlsson, and H. Edlund Phosphorylation Marks IPF1/PDX1 Protein for Degradation by Glycogen Synthase Kinase 3-dependent Mechanisms J. Biol. Chem., March 10, 2006; 281(10): 6395 - 6403. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Lu, H. B. Cottam, M. Corr, and D. A. Carson Repression of {beta}-catenin function in malignant cells by nonsteroidal antiinflammatory drugs PNAS, December 20, 2005; 102(51): 18567 - 18571. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Thorne and C. J. Gottardi Terminating Wnt signals: a novel nuclear export mechanism targets activated {beta}-catenin J. Cell Biol., December 5, 2005; 171(5): 761 - 763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Wallingford and R. Habas The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity Development, October 15, 2005; 132(20): 4421 - 4436. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. E. Reintsch, A. Habring-Mueller, R. W. Wang, A. Schohl, and F. Fagotto {beta}-Catenin controls cell sorting at the notochord-somite boundary independently of cadherin-mediated adhesion J. Cell Biol., August 15, 2005; 170(4): 675 - 686. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Snider and S. J. Tapscott XIC Is Required for Siamois Activity and Dorsoanterior Development Mol. Cell. Biol., June 15, 2005; 25(12): 5061 - 5072. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Broun, L. Gee, B. Reinhardt, and H. R. Bode Formation of the head organizer in hydra involves the canonical Wnt pathway Development, June 15, 2005; 132(12): 2907 - 2916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Benetti, T. Copetti, S. Dell'Orso, E. Melloni, C. Brancolini, M. Monte, and C. Schneider The Calpain System Is Involved in the Constitutive Regulation of {beta}-Catenin Signaling Functions J. Biol. Chem., June 10, 2005; 280(23): 22070 - 22080. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Shimura, Y. Takenaka, T. Fukumori, S. Tsutsumi, K. Okada, V. Hogan, A. Kikuchi, H. Kuwano, and A. Raz Implication of Galectin-3 in Wnt Signaling Cancer Res., May 1, 2005; 65(9): 3535 - 3537. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Quintanilla, F. J. Munoz, M. J. Metcalfe, M. Hitschfeld, G. Olivares, J. A. Godoy, and N. C. Inestrosa Trolox and 17{beta}-Estradiol Protect against Amyloid {beta}-Peptide Neurotoxicity by a Mechanism That Involves Modulation of the Wnt Signaling Pathway J. Biol. Chem., March 25, 2005; 280(12): 11615 - 11625. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Tian, M. C. Feetham, W. A. Tao, X. C. He, L. Li, R. Aebersold, and L. Hood Proteomic analysis identifies that 14-3-3{zeta} interacts with {beta}-catenin and facilitates its activation by Akt PNAS, October 26, 2004; 101(43): 15370 - 15375. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nishiyama, K. Nakayama, R. Tsunematsu, T. Tsukiyama, A. Kikuchi, and K. I. Nakayama Early Embryonic Death in Mice Lacking the {beta}-Catenin-Binding Protein Duplin Mol. Cell. Biol., October 1, 2004; 24(19): 8386 - 8394. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Takada, X. Fang, Md. S. Jamaluddin, D. D. Boyd, and B. B. Aggarwal Genetic Deletion of Glycogen Synthase Kinase-3{beta} Abrogates Activation of I{kappa}B{alpha} Kinase, JNK, Akt, and p44/p42 MAPK but Potentiates Apoptosis Induced by Tumor Necrosis Factor J. Biol. Chem., September 17, 2004; 279(38): 39541 - 39554. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Hulit, C. Wang, Z. Li, C. Albanese, M. Rao, D. Di Vizio, S. Shah, S. W. Byers, R. Mahmood, L. H. Augenlicht, et al. Cyclin D1 Genetic Heterozygosity Regulates Colonic Epithelial Cell Differentiation and Tumor Number in ApcMin Mice Mol. Cell. Biol., September 1, 2004; 24(17): 7598 - 7611. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Sharma, A. Pradeep, L. Wong, A. Rana, and B. Rana Peroxisome Proliferator-activated Receptor {gamma} Activation Can Regulate {beta}-Catenin Levels via a Proteasome-mediated and Adenomatous Polyposis Coli-independent Pathway J. Biol. Chem., August 20, 2004; 279(34): 35583 - 35594. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Yukita, T. Michiue, A. Fukui, K. Sakurai, H. Yamamoto, M. Ihara, A. Kikuchi, and M. Asashima XSENP1, a novel sumo-specific protease in Xenopus, inhibits normal head formation by down-regulation of Wnt/{beta}-catenin signalling Genes Cells, August 1, 2004; 9(8): 723 - 736. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Luchtenborg, M. P. Weijenberg, G. M. J. M. Roemen, A. P. de Bruine, P. A. van den Brandt, M. H. F. M. Lentjes, M. Brink, M. van Engeland, R. A. Goldbohm, and A. F. P. M. de Goeij APC mutations in sporadic colorectal carcinomas from The Netherlands Cohort Study Carcinogenesis, July 1, 2004; 25(7): 1219 - 1226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Sinner, S. Rankin, M. Lee, and A. M. Zorn Sox17 and {beta}-catenin cooperate to regulate the transcription of endodermal genes Development, July 1, 2004; 131(13): 3069 - 3080. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Loughlin, B. Dowling, K. Chapman, L. Marcelline, Z. Mustafa, L. Southam, A. Ferreira, C. Ciesielski, D. A. Carson, and M. Corr Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females PNAS, June 29, 2004; 101(26): 9757 - 9762. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. A. Zeng and E. M. Verheyen Nemo is an inducible antagonist of Wingless signaling during Drosophila wing development Development, June 15, 2004; 131(12): 2911 - 2920. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. E. Weitzel, M. R. Illies, C. A. Byrum, R. Xu, A. H. Wikramanayake, and C. A. Ettensohn Differential stability of {beta}-catenin along the animal-vegetal axis of the sea urchin embryo mediated by dishevelled Development, June 15, 2004; 131(12): 2947 - 2956. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Papadopoulou, M. W. Bianchi, and M. Bourouis Functional Studies of Shaggy/Glycogen Synthase Kinase 3 Phosphorylation Sites in Drosophila melanogaster Mol. Cell. Biol., June 1, 2004; 24(11): 4909 - 4919. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Park, S. I. Kim, M. S. Lee, C.-y. Youn, D. J. Kim, E.-h. Jho, and W. K. Song Modulation of {beta}-Catenin Phosphorylation/Degradation by Cyclin-dependent Kinase 2 J. Biol. Chem., May 7, 2004; 279(19): 19592 - 19599. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Vincent, K. Xiao, K. M. Buckley, and A. P. Kowalczyk VE-cadherin: adhesion at arm's length Am J Physiol Cell Physiol, May 1, 2004; 286(5): C987 - C997. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Lu, Y. Zhao, R. Tawatao, H. B. Cottam, M. Sen, L. M. Leoni, T. J. Kipps, M. Corr, and D. A. Carson Activation of the Wnt signaling pathway in chronic lymphocytic leukemia PNAS, March 2, 2004; 101(9): 3118 - 3123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Matsubayashi, S. Sese, J.-S. Lee, T. Shirakawa, T. Iwatsubo, T. Tomita, and S.-i. Yanagawa Biochemical Characterization of the Drosophila Wingless Signaling Pathway Based on RNA Interference Mol. Cell. Biol., March 1, 2004; 24(5): 2012 - 2024. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F.-Q. Li, R. E. Person, K.-I. Takemaru, K. Williams, K. Meade-White, A. H. Ozsahin, T. Gungor, R. T. Moon, and M. Horwitz Lymphoid Enhancer Factor-1 Links Two Hereditary Leukemia Syndromes through Core-binding Factor {alpha} Regulation of ELA2 J. Biol. Chem., January 23, 2004; 279(4): 2873 - 2884. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Weaver, G. H. Farr III, W. Pan, B. A. Rowning, J. Wang, J. Mao, D. Wu, L. Li, C. A. Larabell, and D. Kimelman GBP binds kinesin light chain and translocates during cortical rotation in Xenopus eggs Development, November 15, 2003; 130(22): 5425 - 5436. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Radu, V. Neubauer, T. Akagi, H. Hanafusa, and M.-M. Georgescu PTEN Induces Cell Cycle Arrest by Decreasing the Level and Nuclear Localization of Cyclin D1 Mol. Cell. Biol., September 1, 2003; 23(17): 6139 - 6149. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Zhang, C. J. Phiel, L. Spece, N. Gurvich, and P. S. Klein Inhibitory Phosphorylation of Glycogen Synthase Kinase-3 (GSK-3) in Response to Lithium: EVIDENCE FOR AUTOREGULATION OF GSK-3 J. Biol. Chem., August 29, 2003; 278(35): 33067 - 33077. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-W. Park, H.-M. Yang, S.-W. Youn, H.-J. Yang, I.-H. Chae, B.-H. Oh, M.-M. Lee, Y.-B. Park, Y.-S. Choi, H.-S. Kim, et al. Constitutively Active Glycogen Synthase Kinase-3{beta} Gene Transfer Sustains Apoptosis, Inhibits Proliferation of Vascular Smooth Muscle Cells, and Reduces Neointima Formation After Balloon Injury in Rats Arterioscler. Thromb. Vasc. Biol., August 1, 2003; 23(8): 1364 - 1369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Sanchez, L. F. Sniderhan, A. L. Williamson, S. Fan, S. Chakraborty-Sett, and S. B. Maggirwar Glycogen Synthase Kinase 3{beta}-Mediated Apoptosis of Primary Cortical Astrocytes Involves Inhibition of Nuclear Factor {kappa}B Signaling |
