![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Research Papers
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139, USA.
Abstract
The neurofibromatosis type II (NF2) tumor suppressor encodes a putative cytoskeletal associated protein, the loss of which leads to the development of Schwann cell tumors associated with NF2 in humans. The NF2 protein merlin belongs to the band 4.1 family of proteins that link membrane proteins to the cytoskeleton and are thought to be involved in dynamic cytoskeletal reorganization. Beyond its membership in this family, however, the function of merlin remains poorly understood. In order to analyze the function of merlin during embryogenesis and to develop a system to study merlin function in detail, we have disrupted the mouse Nf2 gene by homologous recombination in embryonic stem cells. Most embryos homozygous for a mutation at the Nf2 locus fail between embryonic days 6.5 and 7.0, exhibiting a collapsed extraembryonic region and the absence of organized extraembryonic ectoderm. The embryo proper continues to develop, but fails to initiate gastrulation. These observations are supported by the expression patterns of markers of the extraembryonic lineage and the lack of expression of mesodermal markers in the mutant embryos. Mosaic studies demonstrate that merlin function is not required cell autonomously in mesoderm, and support the proposition that merlin function is essential for the development of extraembryonic structures during early mouse development.
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  C. O. Hanemann Magic but treatable? Tumours due to loss of Merlin Brain, March 1, 2008; 131(3): 606 - 615. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. K. Cole, M. Curto, A. W. Chan, and A. I. McClatchey Localization to the Cortical Cytoskeleton Is Necessary for Nf2/Merlin-Dependent Epidermal Growth Factor Receptor Silencing Mol. Cell. Biol., February 15, 2008; 28(4): 1274 - 1284. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Lee, N. F. Silva-Gagliardi, U. Tepass, C. J. McGlade, and K. V. Anderson The FERM protein Epb4.1l5 is required for organization of the neural plate and for the epithelial-mesenchymal transition at the primitive streak of the mouse embryo Development, June 1, 2007; 134(11): 2007 - 2016. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Lee, D. Kim, H. C. Dan, E. L. Wu, T. M. Gritsko, C. Cao, S. V. Nicosia, E. A. Golemis, W. Liu, D. Coppola, et al. Identification and Characterization of Putative Tumor Suppressor NGB, a GTP-Binding Protein That Interacts with the Neurofibromatosis 2 Protein Mol. Cell. Biol., March 15, 2007; 27(6): 2103 - 2119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. McLaughlin, G. M. Kruger, K. L. Slocum, D. Crowley, N. A. Michaud, J. Huang, M. Magendantz, and T. Jacks The Nf2 tumor suppressor regulates cell-cell adhesion during tissue fusion PNAS, February 27, 2007; 104(9): 3261 - 3266. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Morrison, T. Sperka, J. Manent, M. Giovannini, H. Ponta, and P. Herrlich Merlin/Neurofibromatosis Type 2 Suppresses Growth by Inhibiting the Activation of Ras and Rac Cancer Res., January 15, 2007; 67(2): 520 - 527. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. I. McClatchey and M. Giovannini Membrane organization and tumorigenesis--the NF2 tumor suppressor, Merlin Genes & Dev., October 1, 2005; 19(19): 2265 - 2277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. C. Sadler, A. Amsterdam, C. Soroka, J. Boyer, and N. Hopkins A genetic screen in zebrafish identifies the mutants vps18, nf2 and foie gras as models of liver disease Development, August 1, 2005; 132(15): 3561 - 3572. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Rangwala, F. Banine, J.-P. Borg, and L. S. Sherman Erbin Regulates Mitogen-activated Protein (MAP) Kinase Activation and MAP Kinase-dependent Interactions between Merlin and Adherens Junction Protein Complexes in Schwann Cells J. Biol. Chem., March 25, 2005; 280(12): 11790 - 11797. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Y. Lee, H. Kim, C. H. Ryu, J. Y. Kim, B. H. Choi, Y. Lim, P.-W. Huh, Y.-H. Kim, K.-H. Lee, T.-Y. Jun, et al. Merlin, a Tumor Suppressor, Interacts with Transactivation-responsive RNA-binding Protein and Inhibits Its Oncogenic Activity J. Biol. Chem., July 16, 2004; 279(29): 30265 - 30273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. O. Stemmer-Rachamimov, D. N. Louis, G. P. Nielsen, C. R. Antonescu, A. D. Borowsky, R. T. Bronson, D. K. Burns, P. Cervera, M. E. McLaughlin, G. Reifenberger, et al. Comparative Pathology of Nerve Sheath Tumors in Mouse Models and Humans Cancer Res., May 15, 2004; 64(10): 3718 - 3724. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Stickney, W. C. Bacon, M. Rojas, N. Ratner, and W. Ip Activation of the Tumor Suppressor Merlin Modulates Its Interaction with Lipid Rafts Cancer Res., April 15, 2004; 64(8): 2717 - 2724. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Ward and D. E. Devor-Henneman Mouse Models of Human Familial Cancer Syndromes Toxicol Pathol, January 1, 2004; 32(1_suppl): 90 - 98. [Abstract] [PDF]
|
|
|
|
|
|
M. Gronholm, L. Vossebein, C. R. Carlson, J. Kuja-Panula, T. Teesalu, K. Alfthan, A. Vaheri, H. Rauvala, F. W. Herberg, K. Tasken, et al. Merlin Links to the cAMP Neuronal Signaling Pathway by Anchoring the RI{beta} Subunit of Protein Kinase A J. Biol. Chem., October 17, 2003; 278(42): 41167 - 41172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Lallemand, M. Curto, I. Saotome, M. Giovannini, and A. I. McClatchey NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions Genes & Dev., May 1, 2003; 17(9): 1090 - 1100. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gautreau, J. Manent, B. Fievet, D. Louvard, M. Giovannini, and M. Arpin Mutant Products of the NF2 Tumor Suppressor Gene Are Degraded by the Ubiquitin-Proteasome Pathway J. Biol. Chem., August 23, 2002; 277(35): 31279 - 31282. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-X. Sun, V. A. Robb, and D. H. Gutmann Protein 4.1 tumor suppressors: getting a FERM grip on growth regulation J. Cell Sci., January 11, 2002; 115(21): 3991 - 4000. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Auman, T. Nottoli, O. Lakiza, Q. Winger, S. Donaldson, and T. Williams Transcription factor AP-2{gamma} is essential in the extra-embryonic lineages for early postimplantation development Development, January 6, 2002; 129(11): 2733 - 2747. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. H. Gutmann The neurofibromatoses: when less is more Hum. Mol. Genet., April 1, 2001; 10(7): 747 - 755. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Crabtree, P. C. Scacheri, J. M. Ward, L. Garrett-Beal, M. R. Emmert-Buck, K. A. Edgemon, D. Lorang, S. K. Libutti, S. C. Chandrasekharappa, S. J. Marx, et al. A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors PNAS, January 30, 2001; 98(3): 1118 - 1123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Giovannini, E. Robanus-Maandag, M. van der Valk, M. Niwa-Kawakita, V. Abramowski, L. Goutebroze, J. M. Woodruff, A. Berns, and G. Thomas Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2 Genes & Dev., July 1, 2000; 14(13): 1617 - 1630. [Abstract] [Full Text]
|
|
|
|
 |
|
 P. HERRLICH, H. MORRISON, J. SLEEMAN, V. ORIAN-ROUSSEAU, H. KONIG, S. WEG-REMERS, and H. PONTA CD44 Acts Both as a Growth- and Invasiveness-Promoting Molecule and as a Tumor-Suppressing Cofactor Ann. N.Y. Acad. Sci., June 1, 2000; 910(1): 106 - 120. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Cichowski, T. S. Shih, E. Schmitt, S. Santiago, K. Reilly, M. E. McLaughlin, R. T. Bronson, and T. Jacks Mouse Models of Tumor Development in Neurofibromatosis Type 1 Science, December 10, 1999; 286(5447): 2172 - 2176. [Abstract] [Full Text]
|
|
|
|
|
|
C Coffinier, D Thepot, C Babinet, M Yaniv, and J Barra Essential role for the homeoprotein vHNF1/HNF1beta in visceral endoderm differentiation Development, January 11, 1999; 126(21): 4785 - 4794. [Abstract] [PDF]
|
|
|
|
 |
|
 R. S. Lamb, R. E. Ward, L. Schweizer, and R. G. Fehon Drosophila coracle, a Member of the Protein 4.1 Superfamily, Has Essential Structural Functions in the Septate Junctions and Developmental Functions in Embryonic and Adult Epithelial Cells Mol. Biol. Cell, December 1, 1998; 9(12): 3505 - 3519. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. R. LaJeunesse, B. M. McCartney, and R. G. Fehon Structural Analysis of Drosophila Merlin Reveals Functional Domains Important for Growth Control and Subcellular Localization J. Cell Biol., June 29, 1998; 141(7): 1589 - 1599. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. I. McClatchey, I. Saotome, K. Mercer, D. Crowley, J. F. Gusella, R. T. Bronson, and T. Jacks Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors Genes & Dev., April 15, 1998; 12(8): 1121 - 1133. [Abstract] [Full Text]
|
|
|
|
|
|
X. Yang, C. Li, X. Xu, and C. Deng The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice PNAS, March 31, 1998; 95(7): 3667 - 3672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Shaw, A. I. McClatchey, and T. Jacks Regulation of the Neurofibromatosis Type 2 Tumor Suppressor Protein, Merlin, by Adhesion and Growth Arrest Stimuli J. Biol. Chem., March 27, 1998; 273(13): 7757 - 7764. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Shaw, M. Henry, F. Solomon, and T. Jacks RhoA-Dependent Phosphorylation and Relocalization of ERM Proteins into Apical Membrane/Actin Protrusions in Fibroblasts Mol. Biol. Cell, February 1, 1998; 9(2): 403 - 419. [Abstract] [Full Text]
|
|
|
|
|
|
I Dragatsis, A Efstratiadis, and S Zeitlin Mouse mutant embryos lacking huntingtin are rescued from lethality by wild-type extraembryonic tissues Development, January 4, 1998; 125(8): 1529 - 1539. [Abstract] [PDF]
|
|
|
|
|
|
R. Nguyen, D. Reczek, and A. Bretscher Hierarchy of Merlin and Ezrin N- and C-terminal Domain Interactions in Homo- and Heterotypic Associations and Their Relationship to Binding of Scaffolding Proteins EBP50 and E3KARP J. Biol. Chem., March 2, 2001; 276(10): 7621 - 7629. [Abstract] [Full Text] [PDF]
|
|
