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Vol. 11, No. 22,
pp. 3083-3095,
November 15, 1997
1 Institut de Génétique et de Biologie Moléculaire et Cellulaire (I.G.B.M.C.), Centre National de la Recherche Scientifique/Institut National de la Santé et de la Recherche Médicale/Université Louis Pasteur (CNRS/INSERM/ULP), 67404 Illkirch Cedex, Communauté Urbaine de Strasbourg, France; 2 Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138-2020 USA
The pattern of the large sensory bristles on the notum of Drosophila arises as a consequence of the expression of the achaete and scute genes. The gene u-shaped encodes a novel zinc finger that acts as a transregulator of achaete and scute in the dorsal region of the notum. Viable hypomorphic u-shaped mutants display additional dorsocentral and scutellar bristles that result from overexpression of achaete and scute. In contrast, overexpression of u-shaped causes a loss of achaete-scute expression and consequently a loss of dorsal bristles. The effects on the dorsocentral bristles appear to be mediated through the enhancer sequences that regulate achaete and scute at this site. The effects of u-shaped mutants are similar to those of a class of dominant alleles of the gene pannier with which they display allele-specific interactions, suggesting that the products of both genes cooperate in the regulation of achaete and scute. A study of the sites at which the dorsocentral bristles arise in mosaic u-shaped nota, suggests that the levels of the u-shaped protein are crucial for the precise positioning of the precursors of these bristles.
[Key Words: Drosophila; u-shaped; zinc finger protein; bristle pattern; achaete; scute]
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