![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 11, No. 23,
pp. 3122-3127,
December 1, 1997
1 Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724 USA; 2 Graduate Program in Genetics, State University of New York, Stony Brook, New York 11794 USA
Upon infection of human cells, the herpes simplex virus protein
VP16 associates with the endogenous cell-proliferation factor HCF. VP16
can also associate with HCFs from invertebrates, suggesting that VP16
mimics a cellular protein whose interaction with HCF has been
conserved. Here, we show that VP16 mimics the human basic leucine-zipper protein LZIP, which, through association with HCF, may
control cell-cycle progression. VP16 and LZIP share a tetrapeptide motif
D/EHXYused to associate with
human HCF. The LZIP-related Drosophila protein
BBF-2/dCREB-A contains this HCF-binding motif, indicating that the LZIP-HCF interaction has been conserved during metazoan evolution.
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  T. E. Audas, Y. Li, G. Liang, and R. Lu A Novel Protein, Luman/CREB3 Reruitment Factor, Inhibits Luman Activation of the Unfolded Protein Response Mol. Cell. Biol., June 15, 2008; 28(12): 3952 - 3966. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. B. Aicha, J. Lessard, M. Pelletier, A. Fournier, E. Calvo, and C. Labrie Transcriptional profiling of genes that are regulated by the endoplasmic reticulum-bound transcription factor AIbZIP/CREB3L4 in prostate cells Physiol Genomics, October 19, 2007; 31(2): 295 - 305. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. D. Carroll, F. Khadim, S. Spadavecchia, D. Palmeri, and D. M. Lukac Direct Interactions of Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8 ORF50/Rta Protein with the Cellular Protein Octamer-1 and DNA Are Critical for Specifying Transactivation of a Delayed-Early Promoter and Stimulating Viral Reactivation J. Virol., August 15, 2007; 81(16): 8451 - 8467. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Narayanan, W. T. Ruyechan, and T. M. Kristie The coactivator host cell factor-1 mediates Set1 and MLL1 H3K4 trimethylation at herpesvirus immediate early promoters for initiation of infection PNAS, June 26, 2007; 104(26): 10835 - 10840. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Liang, T. E. Audas, Y. Li, G. P. Cockram, J. D. Dean, A. C. Martyn, K. Kokame, and R. Lu Luman/CREB3 Induces Transcription of the Endoplasmic Reticulum (ER) Stress Response Protein Herp through an ER Stress Response Element Mol. Cell. Biol., November 1, 2006; 26(21): 7999 - 8010. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Che, L. Zerboni, M. H. Sommer, and A. M. Arvin Varicella-zoster virus open reading frame 10 is a virulence determinant in skin cells but not in T cells in vivo. J. Virol., April 1, 2006; 80(7): 3238 - 3248. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Misra, N. Rapin, O. Akhova, M. Bainbridge, and P. Korchinski Zhangfei Is a Potent and Specific Inhibitor of the Host Cell Factor-binding Transcription Factor Luman J. Biol. Chem., April 15, 2005; 280(15): 15257 - 15266. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-T. Chin, H.-J. Zhou, C.-M. Wong, J. M.-F. Lee, C.-P. Chan, B.-Q. Qiang, J.-G. Yuan, I. O.-l. Ng, and D.-Y. Jin The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma Nucleic Acids Res., March 30, 2005; 33(6): 1859 - 1873. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Narayanan, M. L. Nogueira, W. T. Ruyechan, and T. M. Kristie Combinatorial Transcription of Herpes Simplex Virus and Varicella Zoster Virus Immediate Early Genes Is Strictly Determined by the Cellular Coactivator HCF-1 J. Biol. Chem., January 14, 2005; 280(2): 1369 - 1375. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-Y. Wong, G. A. Matchett, and A. C. Wilson Transcriptional Activation by the Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Is Facilitated by an N-Terminal Chromatin-Binding Motif J. Virol., September 15, 2004; 78(18): 10074 - 10085. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Khurana and T. M. Kristie A Protein Sequestering System Reveals Control of Cellular Programs by the Transcriptional Coactivator HCF-1 J. Biol. Chem., August 6, 2004; 279(32): 33673 - 33683. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Yokoyama, Z. Wang, J. Wysocka, M. Sanyal, D. J. Aufiero, I. Kitabayashi, W. Herr, and M. L. Cleary Leukemia Proto-Oncoprotein MLL Forms a SET1-Like Histone Methyltransferase Complex with Menin To Regulate Hox Gene Expression Mol. Cell. Biol., July 1, 2004; 24(13): 5639 - 5649. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Nogueira, V. E. H. Wang, D. Tantin, P. A. Sharp, and T. M. Kristie Herpes simplex virus infections are arrested in Oct-1-deficient cells PNAS, February 10, 2004; 101(6): 1473 - 1478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Luciano and A. C. Wilson HCF-1 Functions as a Coactivator for the Zinc Finger Protein Krox20 J. Biol. Chem., December 19, 2003; 278(51): 51116 - 51124. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Wysocka, M. P. Myers, C. D. Laherty, R. N. Eisenman, and W. Herr Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1 Genes & Dev., April 1, 2003; 17(7): 896 - 911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Piluso, P. Bilan, and J. P. Capone Host Cell Factor-1 Interacts with and Antagonizes Transactivation by the Cell Cycle Regulatory Factor Miz-1 J. Biol. Chem., November 22, 2002; 277(48): 46799 - 46808. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Mahajan, M. M. Little, R. Vazquez, and A. C. Wilson Interaction of HCF-1 with a Cellular Nuclear Export Factor J. Biol. Chem., November 8, 2002; 277(46): 44292 - 44299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Luciano and A. C. Wilson An activation domain in the C-terminal subunit of HCF-1 is important for transactivation by VP16 and LZIP PNAS, October 15, 2002; 99(21): 13403 - 13408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Vinson, M. Myakishev, A. Acharya, A. A. Mir, J. R. Moll, and M. Bonovich Classification of Human B-ZIP Proteins Based on Dimerization Properties Mol. Cell. Biol., September 15, 2002; 22(18): 6321 - 6335. [Full Text] [PDF]
|
|
|
|
|
|
C. Raggo, N. Rapin, J. Stirling, P. Gobeil, E. Smith-Windsor, P. O'Hare, and V. Misra Luman, the Cellular Counterpart of Herpes Simplex Virus VP16, Is Processed by Regulated Intramembrane Proteolysis Mol. Cell. Biol., August 15, 2002; 22(16): 5639 - 5649. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Chen, J. Shen, and R. Prywes The Luminal Domain of ATF6 Senses Endoplasmic Reticulum (ER) Stress and Causes Translocation of ATF6 from the ER to the Golgi J. Biol. Chem., April 5, 2002; 277(15): 13045 - 13052. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Lee and W. Herr Stabilization but Not the Transcriptional Activity of Herpes Simplex Virus VP16-Induced Complexes Is Evolutionarily Conserved among HCF Family Members J. Virol., December 15, 2001; 75(24): 12402 - 12411. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Tsavachidou, W. Podrzucki, J. Seykora, and S. L. Berger Gene Array Analysis Reveals Changes in Peripheral Nervous System Gene Expression following Stimuli That Result in Reactivation of Latent Herpes Simplex Virus Type 1: Induction of Transcription Factor Bcl-3 J. Virol., October 15, 2001; 75(20): 9909 - 9917. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Wysocka, P. T. Reilly, and W. Herr Loss of HCF-1-Chromatin Association Precedes Temperature-Induced Growth Arrest of tsBN67 Cells Mol. Cell. Biol., June 1, 2001; 21(11): 3820 - 3829. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Omori, J.-i. Imai, M. Watanabe, T. Komatsu, Y. Suzuki, K. Kataoka, S. Watanabe, A. Tanigami, and S. Sugano CREB-H: a novel mammalian transcription factor belonging to the CREB/ATF family and functioning via the box-B element with a liver-specific expression Nucleic Acids Res., May 15, 2001; 29(10): 2154 - 2162. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Wilson, M. Boutros, K. M. Johnson, and W. Herr HCF-1 Amino- and Carboxy-Terminal Subunit Association through Two Separate Sets of Interaction Modules: Involvement of Fibronectin Type 3 Repeats Mol. Cell. Biol., September 15, 2000; 20(18): 6721 - 6730. [Abstract] [Full Text]
|
|
|
|
|
|
R. Lu and V. Misra Zhangfei: a second cellular protein interacts with herpes simplex virus accessory factor HCF in a manner similar to Luman and VP16 Nucleic Acids Res., June 15, 2000; 28(12): 2446 - 2454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. B. Scarr, M. R. Smith, M. Beddall, and P. A. Sharp A Novel 50-Kilodalton Fragment of Host Cell Factor 1 (C1) in G0 Cells Mol. Cell. Biol., May 15, 2000; 20(10): 3568 - 3575. [Abstract] [Full Text]
|
|
|
|
|
|
S. S. Mahajan and A. C. Wilson Mutations in Host Cell Factor 1 Separate Its Role in Cell Proliferation from Recruitment of VP16 and LZIP Mol. Cell. Biol., February 1, 2000; 20(3): 919 - 928. [Abstract] [Full Text]
|
|
|
|
|
|
P. M. Ajuh, G. J. Browne, N. A. Hawkes, P. T. W. Cohen, S. G. E. Roberts, and A. I. Lamond Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex Nucleic Acids Res., February 1, 2000; 28(3): 678 - 686. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Lu and V. Misra Potential Role for Luman, the Cellular Homologue of Herpes Simplex Virus VP16 (alpha Gene trans-Inducing Factor), in Herpesvirus Latency J. Virol., January 1, 2000; 74(2): 934 - 943. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Liu, W. Gong, C. C. Huang, W. Herr, and X. Cheng Crystal structure of the conserved core of the herpes simplex virus transcriptional regulatory protein VP16 Genes & Dev., July 1, 1999; 13(13): 1692 - 1703. [Abstract] [Full Text]
|
|
|
|
|
|
K. M. Johnson, S. S. Mahajan, and A. C. Wilson Herpes Simplex Virus Transactivator VP16 Discriminates between HCF-1 and a Novel Family Member, HCF-2 J. Virol., May 1, 1999; 73(5): 3930 - 3940. [Abstract] [Full Text]
|
|
|
|
|
|
G. Jimenez, C. P. Verrijzer, and D. Ish-Horowicz A Conserved Motif in Goosecoid Mediates Groucho-Dependent Repression in Drosophila Embryos Mol. Cell. Biol., March 1, 1999; 19(3): 2080 - 2087. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Liu, M. O. Hengartner, and W. Herr Selected Elements of Herpes Simplex Virus Accessory Factor HCF Are Highly Conserved in Caenorhabditis elegans Mol. Cell. Biol., January 1, 1999; 19(1): 909 - 915. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Lu, P. Yang, S. Padmakumar, and V. Misra The Herpesvirus Transactivator VP16 Mimics a Human Basic Domain Leucine Zipper Protein, Luman, in Its Interaction with HCF J. Virol., August 1, 1998; 72(8): 6291 - 6297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lin, P. Puigserver, J. Donovan, P. Tarr, and B. M. Spiegelman Peroxisome Proliferator-activated Receptor gamma Coactivator 1beta (PGC-1beta ), A Novel PGC-1-related Transcription Coactivator Associated with Host Cell Factor J. Biol. Chem., January 11, 2002; 277(3): 1645 - 1648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-J. Zhou, C.-M. Wong, J.-H. Chen, B.-Q. Qiang, J.-G. Yuan, and D.-Y. Jin Inhibition of LZIP-mediated Transcription through Direct Interaction with a Novel Host Cell Factor-like Protein J. Biol. Chem., July 27, 2001; 276(31): 28933 - 28938. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Vogel and T. M. Kristie Autocatalytic proteolysis of the transcription factor-coactivator C1 (HCF): A potential role for proteolytic regulation of coactivator function PNAS, August 15, 2000; 97(17): 9425 - 9430. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Luciano and A. C. Wilson N-terminal transcriptional activation domain of LZIP comprises two LxxLL motifs and the Host Cell Factor-1 binding motif PNAS, September 26, 2000; 97(20): 10757 - 10762. [Abstract] [Full Text] [PDF]
|
|
