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Vol. 12, No. 10, pp. 1474-1482, May 15, 1998
Howard Hughes Medical Institute and Laboratory of Molecular
Biology, University of Wisconsin, Madison, Wisconsin 53706 USA
Arthropods and vertebrates are constructed of many serially
homologous structures whose individual patterns are regulated by
Hox genes. The Hox-regulated target genes and developmental pathways that determine the morphological differences between any
homologous structures are not known. The differentiation of the
Drosophila haltere from the wing through the action of the Ultrabithorax (Ubx) gene is a classic example of
Hox regulation of serial homology, although no Ubx-regulated
genes in the haltere have been identified previously. Here, we show
that Ubx represses the expression of the Wingless (Wg) signaling
protein and a subset of Wg- and Decapentaplegic-activated genes such as
spalt-related, vestigial, Serum Response Factor, and
achaete-scute, whose products regulate morphological features
that differ between the wing and haltere. In addition, we found that
some genes in the same developmental pathway are independently
regulated by Ubx. Our results suggest that Ubx, and Hox genes
in general, independently and selectively regulate genes that act at
many levels of regulatory hierarchies to shape the differential
development of serially homologous structures.
[Key Words: Ultrabithorax; haltere; development; Drosophila; serial homology]
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