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Vol. 12, No. 11, pp. 1665-1677, June 1, 1998
1 Department of Molecular Genetics and Microbiology and
2 Graduate Program in Molecular Biosciences at University
of Medicine and Dentistry of New Jersey (UMDNJ)/Rutgers
Universities, Robert Wood Johnson Medical School-UMDNJ,
3 Institute of Experimental Cardiology, Cardiology Research
Center, Moscow, 121552 Russia;
4 Department of Pediatrics, The nonsense-mediated mRNA decay pathway is an example of an
evolutionarily conserved surveillance pathway that rids the cell of
transcripts that contain nonsense mutations. The product of the
UPF1 gene is a necessary component of the putative surveillance complex that recognizes and degrades aberrant mRNAs. Recent results indicate that the Upf1p also enhances translation termination at a
nonsense codon. The results presented here demonstrate that the yeast
and human forms of the Upf1p interact with both eukaryotic translation
termination factors eRF1 and eRF3. Consistent with Upf1p interacting
with the eRFs, the Upf1p is found in the prion-like aggregates that
contain eRF1 and eRF3 observed in yeast [PSI+] strains.
These results suggest that interaction of the Upf1p with the peptidyl
release factors may be a key event in the assembly of the putative
surveillance complex that enhances translation termination, monitors
whether termination has occurred prematurely, and promotes degradation
of aberrant transcripts.
[Key Words:
mRNA decay; translation termination; release
factors; nonsense mutation; ribosome; mRNA surveillance]
GENES & DEVELOPMENT 12:1665-1677 © 1998 by Cold Spring Harbor Laboratory Press ISSN 0890-9369/98 $5.00
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