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Vol. 12, No. 13, pp. 2036-2047, July 1, 1998
Centro de Biología Molecular Severo Ochoa, Consejo Superior
de Investigaciones Científicas and Universidad
Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain
To learn about the acquisition of neural fate by ectodermal cells,
we have analyzed a very early sign of neural commitment in
Drosophila, namely the specific accumulation of
achaete-scute complex (AS-C) proneural proteins in the cell
that becomes a sensory organ mother cell (SMC). We have characterized
an AS-C enhancer that directs expression specifically in SMCs. This
enhancer promotes Scute protein accumulation in these cells, an event
essential for sensory organ development in the absence of other AS-C
genes. Interspecific sequence comparisons and site-directed mutagenesis show the presence of several conserved motifs necessary for enhancer action, some of them binding sites for proneural proteins. These and
other data indicate that the enhancer mediates scute
self-stimulation, although only in the presence of additional
activating factors, which most likely interact with conserved motifs
reminiscent of NF-
B-binding sites. Cells neighboring the SMC do
not acquire the neural fate because the Notch signaling pathway
effectors, the Enhancer of split bHLH proteins, block this
proneural gene self-stimulatory loop, possibly by antagonizing the
action on the enhancer of the NF-B-like factors or the proneural
proteins. These data suggest a mechanism for SMC committment.
[Key Words: Neurogenesis; proneural gene; Notch; E(spl) complex; achaete-scute complex; Drosophila]
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