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Vol. 12, No. 14, pp. 2108-2113, July 15, 1998
1 U 383 Institut National de la Santé et de la
Recherche Médicale (INSERM), and
3 Laboratoire de
Fécondation in Vitro Hôpital, Necker-Enfants Malades, 75743 Paris Cedex 15, France;
2 Centre National de la Recherche
Scientifique (CNRS), Université J. Fourier de Grenoble, 38706 La
Tronche, France;
4 U 257 INSERM, Institut Cochin de
Génétique Moléculaire (ICGM), Centre Hospitalier
Universitaire-Cochin, 75014 Paris, France
DNA methylation patterns were evaluated during preimplantation
mouse development by analyzing the binding of monoclonal antibody to
5-methylcytosine (5-MeC) on metaphase chromosomes. Specific chromosome
patterns were observed in each cell stage. A banding pattern
predominated in chromosomes at the one-cell stage. Banding was replaced
at the two-cell stage by an asymmetrical labeling of the sister
chromatids. Then, the proportion of asymmetrical chromosomes decreased
by one-half at each cell division until the blastocyst stage, and
chromosomes became progressively symmetrical and weakly labeled. Our
results indicate that chromosome demethylation is associated with each
DNA replication and suggest that a passive mechanism predominates
during early development.
[Key Words: DNA methylation; mammalian chromosomes; preimplantation embryos]
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