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Vol. 12, No. 17, pp. 2664-2672, September 1, 1998
1 Cold Spring Harbor Laboratory and
2 Howard
Hughes Medical Institute, Cold Spring Harbor, New York 11724 USA
The basal transcription factor SNAPc binds to the PSE, a
core element in the RNA polymerase II and III human snRNA promoters. SNAPc contains at least four subunits, but it has not been
possible to assemble a fully defined recombinant SNAPc. Here
we reconstitute SNAPc from five recombinant subunits, SNAP43,
SNAP45, SNAP50, SNAP190, and a newly identified subunit, SNAP19. This
recombinant complex binds specifically to the PSE and directs both RNA
polymerase II and III snRNA gene transcription. Thus, the same core
SNAPc nucleates the assembly of two classes of initiation
complexes.
[Key Words: SNAPc; human snRNA promoters; RNA polymerases; transcription]
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