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Vol. 12, No. 17, pp. 2724-2734, September 1, 1998

RESEARCH PAPER
A novel homeobox gene mediates the Dpp signal to establish functional specificity within target cells

Hideki Nakagoshi,1,2,6 Minako Hoshi,1 Yo-ichi Nabeshima,1,4 and Fumio Matsuzaki1,3,5,6

1 Department of Molecular Genetics, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8502, Japan; 2 Precursory Research for Embryonic Science and Technology (PRESTO) and 3 Core Research for Evolutional Science and Technology (CREST) of Japan Science and Technology Corporation (JST); 4 Institute for Molecular and Cellular Biology, Osaka University, Suita, Osaka 565-0871, Japan; 5 Department of Developmental Neurobiology, Institute of Development, Aging and Cancer, Tohoku University, Aoba-ku, Sendai 980-8575, Japan

Morphogen gradients of secreted molecules play critical roles in the establishment of the spatial pattern of gene expression. During midgut development in Drosophila, secreted molecules of Decapentaplegic (Dpp) and Wingless (Wg) establish unique transcriptional regulation within target cells to specify the resultant cell types. Here we report the identification of a novel homeobox gene, defective proventriculus (dve), which is required for the midgut specification under the control of Dpp and Wg. In dve mutants, two distinct parts of the midgut, the proventriculus and middle midgut, are abnormally organized. The Wg signal regulates dve expression during proventriculus development. On the other hand, dve is a downstream target of Dpp in the middle midgut and defines the functional specificity of copper cells along with another Dpp target gene, labial. Thus, the dve gene acts under the two distinct extracellular signals at distant parts of the midgut primordia.

[Key Words: Homeodomain; Dpp; Wg; midgut; functional specificity]

GENES & DEVELOPMENT 12:2724-2734 © 1998 by Cold Spring Harbor Laboratory Press  ISSN 0890-9369/98 $5.00
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