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Vol. 12, No. 2, pp. 198-207, January 15, 1998
Department of Biology, Indiana University,
Bloomington, Indiana 47405 USA
Genetic analysis in Arabidopsis has led to the
identification of several genes that are required for auxin response.
One of these genes, AXR1, encodes a protein related to yeast
Aos1p, a protein that functions to activate the ubiquitin-related
protein Smt3p. Here we report the identification of a new gene called TRANSPORT INHIBITOR RESPONSE 1 (TIR1). The tir1
mutants are deficient in a variety of auxin-regulated growth processes
including hypocotyl elongation and lateral root formation. These
results indicate that TIR1 is also required for normal response
to auxin. Further, mutations in TIR1 display a synergistic
interaction with mutations in AXR1, suggesting that the two
genes function in overlapping pathways. The TIR1 protein contains a
series of leucine-rich repeats and a recently identified motif called
an F box. Sequence comparisons indicate that TIR1 is related to the
yeast protein Grr1p and the human protein SKP2. Because Grr1p and other
F-box proteins have been implicated in ubiquitin-mediated processes, we
speculate that auxin response depends on the modification of a key
regulatory protein(s) by ubiquitin or a ubiquitin-related protein.
[Key Words: F-box protein; Arabidopsis; auxin response; TIR1; human SKP2; yeast Grr1p]
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