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Vol. 12, No. 21, pp. 3320-3324, November 1, 1998
1 Department of Molecular Genetics,
2 Department
of Biochemistry,
3 Howard Hughes Medical Institute, University
of Texas Southwestern Medical Center, Dallas, Texas 75235 USA;
4 Gerontology Research Education and Clinical Center, Veterans
Administration Medical Center and Department of Medicine, University of
Washington School of Medicine, Seattle, Washington 98195 USA
Mice lacking the hypoxia-inducible transcription factor EPAS1 die
at mid-gestation. Despite normal morphological development of the
circulatory system, EPAS1-deficient mice display pronounced bradycardia. In addition to the vascular endothelium, EPAS1 is expressed intensively in the organ of Zuckerkandl (OZ), the principle source of catecholamine production in mammalian embryos.
EPAS1-deficient embryos contained substantially reduced catecholamine
levels. Mid-gestational lethality was rescued by administration of the catecholamine precursor DOPS to pregnant females. We hypothesize that
EPAS1 expressed in the OZ senses hypoxia during mid-gestational development and translates this signal into an altered pattern of gene
expression, leading to increases in circulating catecholamine levels
and proper cardiac function.
[Key Words: EPAS1; hypoxia; gene targeting]
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|
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|
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|
|
|
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|
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|
|
|
|
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|
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|
|
|
|
|
|
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|
|
|
|
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|
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|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 G. L. Semenza O2-regulated gene expression: transcriptional control of cardiorespiratory physiology by HIF-1 J Appl Physiol, March 1, 2004; 96(3): 1173 - 1177. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
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|
|
|
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