![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 12, No. 21, pp. 3394-3407, November 1, 1998
Howard Hughes Medical Institute (HHMI), Department of Biochemistry
and Molecular Biophysics, Center for Neurobiology and Behavior,
Columbia University, New York, New York 10032 USA
Inductive factors are known to direct the regional differentiation
of the vertebrate central nervous system (CNS) but their role in the
specification of individual neuronal cell types is less clear. We have
examined the function of GDF7, a BMP family member expressed
selectively by roof plate cells, in the generation of neuronal cell
types in the dorsal spinal cord. We find that GDF7 can promote the
differentiation in vitro of two dorsal sensory interneuron classes, D1A
and D1B neurons. In Gdf7-null mutant embryos, the generation of
D1A neurons is eliminated but D1B neurons and other identified dorsal
interneurons are unaffected. These findings show that GDF7 is an
inductive signal from the roof plate required for the specification of
neuronal identity in the dorsal spinal cord and that GDF7 and other BMP
family members expressed by the roof plate have non-redundant functions
in vivo. More generally, these results suggest that BMP signaling may
have a prominent role in the assignment of neuronal identity within the
mammalian CNS.
[Key Words: BMPs; neural patterning; spinal cord; commissural neurons]
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  K. Yamauchi, K. D. Phan, and S. J. Butler BMP type I receptor complexes have distinct activities mediating cell fate and axon guidance decisions Development, March 15, 2008; 135(6): 1119 - 1128. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Gerhart, C. Neely, J. Elder, J. Pfautz, J. Perlman, L. Narciso, K. K. Linask, K. Knudsen, and M. George-Weinstein Cells that express MyoD mRNA in the epiblast are stably committed to the skeletal muscle lineage J. Cell Biol., August 9, 2007; 178(4): 649 - 660. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-L. Chen and D. M. Panchision Concise Review: Bone Morphogenetic Protein Pleiotropism in Neural Stem Cells and Their Derivatives--Alternative Pathways, Convergent Signals Stem Cells, January 1, 2007; 25(1): 63 - 68. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. V. Chizhikov, A. G. Lindgren, D. S. Currle, M. F. Rose, E. S. Monuki, and K. J. Millen The roof plate regulates cerebellar cell-type specification and proliferation Development, August 1, 2006; 133(15): 2793 - 2804. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Alexandre, I. Bachy, M. Marcou, and M. Wassef Positive and negative regulations by FGF8 contribute to midbrain roof plate developmental plasticity Development, August 1, 2006; 133(15): 2905 - 2913. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Mazerbourg and A. J.W. Hsueh Genomic analyses facilitate identification of receptors and signalling pathways for growth differentiation factor 9 and related orphan bone morphogenetic protein/growth differentiation factor ligands Hum. Reprod. Update, July 1, 2006; 12(4): 373 - 383. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Mazerbourg, K. Sangkuhl, C.-W. Luo, S. Sudo, C. Klein, and A. J. W. Hsueh Identification of Receptors and Signaling Pathways for Orphan Bone Morphogenetic Protein/Growth Differentiation Factor Ligands Based on Genomic Analyses J. Biol. Chem., September 16, 2005; 280(37): 32122 - 32132. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Li, K. Misra, M. P. Matise, and M. Xiang Foxn4 acts synergistically with Mash1 to specify subtype identity of V2 interneurons in the spinal cord PNAS, July 26, 2005; 102(30): 10688 - 10693. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. W. Helms, J. Battiste, R. M. Henke, Y. Nakada, N. Simplicio, F. Guillemot, and J. E. Johnson Sequential roles for Mash1 and Ngn2 in the generation of dorsal spinal cord interneurons Development, June 15, 2005; 132(12): 2709 - 2719. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hester, J. C. Thompson, J. Mills, Y. Liu, H. M. El-Hodiri, and M. Weinstein Smad1 and Smad8 Function Similarly in Mammalian Central Nervous System Development Mol. Cell. Biol., June 1, 2005; 25(11): 4683 - 4692. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Lo, E. L. Dormand, and D. J. Anderson Late-emigrating neural crest cells in the roof plate are restricted to a sensory fate by GDF7 PNAS, May 17, 2005; 102(20): 7192 - 7197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Charron and M. Tessier-Lavigne Novel brain wiring functions for classical morphogens: a role as graded positional cues in axon guidance Development, May 15, 2005; 132(10): 2251 - 2262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-Q. Ding, J.-Y. Kim, Y.-S. Xu, Y. Rao, and Z.-F. Chen Ventral migration of early-born neurons requires Dcc and is essential for the projections of primary afferents in the spinal cord Development, May 1, 2005; 132(9): 2047 - 2056. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Muller, K. Anlag, H. Wildner, S. Britsch, M. Treier, and C. Birchmeier The bHLH factor Olig3 coordinates the specification of dorsal neurons in the spinal cord Genes & Dev., March 15, 2005; 19(6): 733 - 743. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Mizuhara, T. Nakatani, Y. Minaki, Y. Sakamoto, and Y. Ono Corl1, a Novel Neuronal Lineage-specific Transcriptional Corepressor for the Homeodomain Transcription Factor Lbx1 J. Biol. Chem., February 4, 2005; 280(5): 3645 - 3655. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H Hutchings, H Ginisty, M Le Gallo, D Levy, F Stoesser, J F Rouland, J L Arne, M H Lalaux, P Calvas, M P Roth, et al. Identification of a new locus for isolated familial keratoconus at 2p24 J. Med. Genet., January 1, 2005; 42(1): 88 - 94. [Full Text] [PDF]
|
|
|
|
|
|
L. Wine-Lee, K. J. Ahn, R. D. Richardson, Y. Mishina, K. M. Lyons, and E. B. Crenshaw III Signaling through BMP type 1 receptors is required for development of interneuron cell types in the dorsal spinal cord Development, November 1, 2004; 131(21): 5393 - 5403. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. V. Chizhikov and K. J. Millen Control of Roof Plate Development and Signaling by Lmx1b in the Caudal Vertebrate CNS J. Neurosci., June 23, 2004; 24(25): 5694 - 5703. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. V. Chizhikov and K. J. Millen Control of roof plate formation by Lmx1a in the developing spinal cord Development, June 1, 2004; 131(11): 2693 - 2705. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. V. Bulgakov, J. T. Eggenschwiler, D.-H. Hong, K. V. Anderson, and T. Li FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues Development, May 1, 2004; 131(9): 2149 - 2159. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. O. Gaufo, S. Wu, and M. R. Capecchi Contribution of Hox genes to the diversity of the hindbrain sensory system Development, March 15, 2004; 131(6): 1259 - 1266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Liu, A. W. Helms, and J. E. Johnson Distinct activities of Msx1 and Msx3 in dorsal neural tube development Development, March 1, 2004; 131(5): 1017 - 1028. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Gazit, V. Krizhanovsky, and N. Ben-Arie Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway Development, February 15, 2004; 131(4): 903 - 913. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Alexandre and M. Wassef The isthmic organizer links anteroposterior and dorsoventral patterning in the mid/hindbrain by generating roof plate structures Development, November 15, 2003; 130(22): 5331 - 5338. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bach, Y. Lallemand, M.-A. Nicola, C. Ramos, L. Mathis, M. Maufras, and B. Robert Msx1 is required for dorsal diencephalon patterning Development, September 1, 2003; 130(17): 4025 - 4036. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. P. Mortlock, C. Guenther, and D. M. Kingsley A General Approach for Identifying Distant Regulatory Elements Applied to the Gdf6 Gene Genome Res., September 1, 2003; 13(9): 2069 - 2081. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Winkler, M. Schafer, J. Duschl, M. Schartl, and J.-N. Volff Functional Divergence of Two Zebrafish Midkine Growth Factors Following Fish-Specific Gene Duplication Genome Res., June 1, 2003; 13(6): 1067 - 1081. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Mizuseki, T. Sakamoto, K. Watanabe, K. Muguruma, M. Ikeya, A. Nishiyama, A. Arakawa, H. Suemori, N. Nakatsuji, H. Kawasaki, et al. Generation of neural crest-derived peripheral neurons and floor plate cells from mouse and primate embryonic stem cells PNAS, May 13, 2003; 100(10): 5828 - 5833. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Ebert, J. R. Timmer, Y. Nakada, A. W. Helms, P. B. Parab, Y. Liu, T. L. Hunsaker, and J. E. Johnson Zic1 represses Math1 expression via interactions with the Math1 enhancer and modulation of Math1 autoregulation Development, May 1, 2003; 130(9): 1949 - 1959. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Timmer, C. Wang, and L. Niswander BMP signaling patterns the dorsal and intermediate neural tube via regulation of homeobox and helix-loop-helix transcription factors Development, March 7, 2003; 129(10): 2459 - 2472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Vogel-Hopker and H. Rohrer The specification of noradrenergic locus coeruleus (LC) neurones depends on bone morphogenetic proteins (BMPs) Development, March 4, 2003; 129(4): 983 - 991. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. Rusten, R. Cantera, F. C. Kafatos, and R. Barrio The role of TGF{beta} signaling in the formation of the dorsal nervous system is conserved between Drosophila and chordates Development, August 1, 2002; 129(15): 3575 - 3584. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Qian, S. Shirasawa, C.-L. Chen, L. Cheng, and Q. Ma Proper development of relay somatic sensory neurons and D2/D4 interneurons requires homeobox genes Rnx/Tlx-3 and Tlx-1 Genes & Dev., May 15, 2002; 16(10): 1220 - 1233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Muroyama, M. Fujihara, M. Ikeya, H. Kondoh, and S. Takada Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord Genes & Dev., March 1, 2002; 16(5): 548 - 553. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Panchision, J. M. Pickel, L. Studer, S.-H. Lee, P. A. Turner, T. G. Hazel, and R. D.G. McKay Sequential actions of BMP receptors control neural precursor cell production and fate Genes & Dev., August 15, 2001; 15(16): 2094 - 2110. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Dionne, W. C. Skarnes, and R. M. Harland Mutation and Analysis of Dan, the Founding Member of the Dan Family of Transforming Growth Factor {beta} Antagonists Mol. Cell. Biol., January 15, 2001; 21(2): 636 - 643. [Abstract] [Full Text]
|
|
|
|
|
|
J. C. Lin, L. Cai, and C. L. Cepko The External Granule Layer of the Developing Chick Cerebellum Generates Granule Cells and Cells of the Isthmus and Rostral Hindbrain J. Neurosci., January 1, 2001; 21(1): 159 - 168. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. López-Coviella, B. Berse, R. Krauss, R. S. Thies, and J. K. Blusztajn Induction and Maintenance of the Neuronal Cholinergic Phenotype in the Central Nervous System by BMP-9 Science, July 14, 2000; 289(5477): 313 - 316. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. Bulfone, E. Menguzzato, V. Broccoli, A. Marchitiello, C. Gattuso, M. Mariani, G. G. Consalez, S. Martinez, A. Ballabio, and S. Banfi Barhl1, a gene belonging to a new subfamily of mammalian homeobox genes, is expressed in migrating neurons of the CNS Hum. Mol. Genet., May 22, 2000; 9(9): 1443 - 1452. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Glover Development of Specific Connectivity Between Premotor Neurons and Motoneurons in the Brain Stem and Spinal Cord Physiol Rev, April 1, 2000; 80(2): 615 - 647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Shou, R. Murray, P. Rim, and A. Calof Opposing effects of bone morphogenetic proteins on neuron production and survival in the olfactory receptor neuron lineage Development, January 12, 2000; 127(24): 5403 - 5413. [Abstract] [PDF]
|
|
|
|
|
|
D Sela-Donenfeld and C Kalcheim Inhibition of noggin expression in the dorsal neural tube by somitogenesis: a mechanism for coordinating the timing of neural crest emigration Development, January 11, 2000; 127(22): 4845 - 4854. [Abstract] [PDF]
|
|
|
|
|
|
K. Liem, T. Jessell, and J Briscoe Regulation of the neural patterning activity of sonic hedgehog by secreted BMP inhibitors expressed by notochord and somites Development, January 11, 2000; 127(22): 4855 - 4866. [Abstract] [PDF]
|
|
|
|
|
|
A Louvi and M Wassef Ectopic engrailed 1 expression in the dorsal midline causes cell death, abnormal differentiation of circumventricular organs and errors in axonal pathfinding Development, January 9, 2000; 127(18): 4061 - 4071. [Abstract] [PDF]
|
|
|
|
|
|
N Ben-Arie, B. Hassan, N. Bermingham, D. Malicki, D Armstrong, M Matzuk, H. Bellen, and H. Zoghbi Functional conservation of atonal and Math1 in the CNS and PNS Development, January 3, 2000; 127(5): 1039 - 1048. [Abstract] [PDF]
|
|
|
|
|
|
V. Nguyen, J Trout, S. Connors, P Andermann, E Weinberg, and M. Mullins Dorsal and intermediate neuronal cell types of the spinal cord are established by a BMP signaling pathway Development, January 3, 2000; 127(6): 1209 - 1220. [Abstract] [PDF]
|
|
|
|
|
|
S. Lee, S Tole, E Grove, and A. McMahon A local Wnt-3a signal is required for development of the mammalian hippocampus Development, January 2, 2000; 127(3): 457 - 467. [Abstract] [PDF]
|
|
|
|
|
|
J Galceran, E. Miyashita-Lin, E Devaney, J. Rubenstein, and R Grosschedl Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1 Development, January 2, 2000; 127(3): 469 - 482. [Abstract] [PDF]
|
|
|
|
|
|
D. H. Rowitch, B. St.-Jacques, S. M. K. Lee, J. D. Flax, E. Y. Snyder, and A. P. McMahon Sonic hedgehog Regulates Proliferation and Inhibits Differentiation of CNS Precursor Cells J. Neurosci., October 15, 1999; 19(20): 8954 - 8965. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L.R. Rubenstein, S. Anderson, L. Shi, E. Miyashita-Lin, A. Bulfone, and R. Hevner Genetic Control of Cortical Regionalization and Connectivity Cereb Cortex, September 1, 1999; 9(6): 524 - 532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. I. Zon Zebrafish: A New Model for Human Disease Genome Res., February 1, 1999; 9(2): 99 - 100. [Full Text]
|
|
|
|
|
|
A. J. Davidson, J. H. Postlethwait, Y.-L. Yan, D. R. Beier, C. van Doren, D. Foernzler, A. J. Celeste, K. E. Crosier, and P. S. Crosier Isolation of Zebrafish gdf7 and Comparative Genetic Mapping of Genes Belonging to the Growth/Differentiation Factor 5, 6, 7 Subgroup of the TGF-beta Superfamily Genome Res., February 1, 1999; 9(2): 121 - 129. [Abstract] [Full Text]
|
|
|
|
|
|
D Sela-Donenfeld and C Kalcheim Regulation of the onset of neural crest migration by coordinated activity of BMP4 and Noggin in the dorsal neural tube Development, January 11, 1999; 126(21): 4749 - 4762. [Abstract] [PDF]
|
|
|
|
|
|
H Saueressig, J Burrill, and M Goulding Engrailed-1 and netrin-1 regulate axon pathfinding by association interneurons that project to motor neurons Development, January 10, 1999; 126(19): 4201 - 4212. [Abstract] [PDF]
|
|
|
|
|
|
C Chang and A Hemmati-Brivanlou Xenopus GDF6, a new antagonist of noggin and a partner of BMPs Development, January 8, 1999; 126(15): 3347 - 3357. [Abstract] [PDF]
|
|
|
|
|
|
K Dale, N Sattar, J Heemskerk, J. Clarke, M Placzek, and J Dodd Differential patterning of ventral midline cells by axial mesoderm is regulated by BMP7 and chordin Development, January 1, 1999; 126(2): 397 - 408. [Abstract] [PDF]
|
|
