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Vol. 12, No. 24, pp. 3809-3814, December 15, 1998
1 Department of Molecular, Cellular, and Developmental
Biology and Neuroscience Research Institute, University of California,
Santa Barbara, California 93106 USA;
2 Department of
Biochemistry and Molecular Biology, University of Calgary, Calgary,
Alberta T2N 4N1, Canada
The END-1 GATA factor has been implicated in specifying endoderm
in Caenorhabditis elegans and is the earliest known zygotic protein expressed in the lineage of E, the clonal endoderm progenitor. We report that ubiquitous end-1 expression during a critical
period in embryogenesis causes all non-endodermal lineages to produce endoderm instead of ectoderm and/or mesoderm. END-1
expression bypasses the requirement for maternal SKN-1 and the maternal
Wnt signaling pathway in endoderm formation. This suggests that a primary function of these maternal factors is to regulate zygotic end-1 expression, which is then sufficient to initiate the
entire program for endoderm development.
[Key Words: C. elegans; endoderm; end-1; GATA factor; germ layer; cell fate]
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