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Vol. 12, No. 24, pp. 3815-3820, December 15, 1998
1 Banting and Best Department of Medical Research,
Charles H. Best Institute, University of Toronto, Ontario M5G 1L6,
Canada;
2 Department of Biological Sciences, University of
Alberta, Edmonton, Alberta T6G 2E9, Canada;
3 Waksman
Institute and Department of Molecular Biology and Biochemistry,
Rutgers, The State University, Piscataway, New Jersey 08854 USA
Scalloped (Sd) and Vestigial (Vg) are each needed for
Drosophila wing development. We show that Sd is required for Vg
function and that altering their relative cellular levels inhibits wing formation. In vitro, Vg binds directly to both Sd and its human homolog, Transcription Enhancer Factor-1. The interaction domains map
to a small region of Vg that is essential for Vg-mediated gene
activation and to the carboxy-terminal half of Sd. Our observations indicate that Vg and Sd function coordinately to control the expression of genes required for wing development, which implies that Vg is a
tissue-specific transcriptional intermediary factor of Sd.
[Key Words: Vestigial; Scalloped; Wing; Drosphila; transcription; development]
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