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Vol. 12, No. 3, pp. 304-315, February 1, 1998
1 Centro de Biologia Molecular "Severo Ochoa,"
C.S.I.C.-Universidad Autonoma, 28049 Madrid, Spain;
2 Institute of Molecular and Cell Biology, National
University of Singapore, Singapore
Each larval hemisegment comprises ~30 uniquely specified
somatic muscles. These derive from muscle founders that arise as distinct sibling pairs from the division of muscle progenitor cells. We
have analyzed the progenitor cell divisions of three mesodermal
lineages that generate muscle (and pericardial cell) founders. Our
results show that Inscuteable and Numb proteins are localized as
cortical crescents on opposite sides of dividing progenitor cells.
Asymmetric segregation of Numb into one of the sibling myoblasts
depends on inscuteable and is essential for the specification
of distinct sibling cell fates. Loss of numb or
inscuteable results in opposite cell fate transformations
both prevent sibling myoblasts from adopting distinct identities, resulting in duplicated or deleted mesodermal structures. Our results indicate that the muscle progenitor cell divisions are intrinsically asymmetric; moreover, the involvement of both inscuteable and
numb/N suggests that the specification of the
distinct cell fates of sibling myoblasts requires intrinsic and
extrinsic cues.
[Key Words: Myogenesis; asymmetric cell division; muscle progenitor]
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