![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 12, No. 4, pp. 473-479, February 15, 1998
Division of Hematology-Oncology, Children's Hospital and the
Dana Farber Cancer Center, Department of Pediatrics, and the Howard
Hughes Medical Institute, Harvard Medical School,
Boston, Massachusetts 02115 USA
The transcription factor SCL/tal-1 is essential for
blood cell development. Though it is also expressed in vascular
endothelium, SCL has been considered dispensable for vessel formation.
Through transgenic rescue of hematopoietic defects of
SCL
/ embryos and analysis of chimeras
generated with SCL/ ES cells tagged
with a transgene expressed in vascular endothelial cells, we show that
SCL is essential for angiogenic remodeling of the yolk sac capillary
network into complex vitelline vessels. These findings establish a role
for SCL in embryonic angiogenesis and argue for critical functions in
both embryonic blood and vascular cells, the descendents of the
presumptive hemangioblast.
[Key Words: SCL/tal-1 gene; hematopoiesis; vascular development; tie-2 gene]
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  W. Tan, T. R. Palmby, J. Gavard, P. Amornphimoltham, Y. Zheng, and J. S. Gutkind An essential role for Rac1 in endothelial cell function and vascular development FASEB J, June 1, 2008; 22(6): 1829 - 1838. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. McCrann, T. Yezefski, H. G. Nguyen, N. Papadantonakis, H. Liu, Q. Wen, J. D. Crispino, and K. Ravid Survivin overexpression alone does not alter megakaryocyte ploidy nor interfere with erythroid/megakaryocytic lineage development in transgenic mice Blood, April 15, 2008; 111(8): 4092 - 4095. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-R. Landry, S. Kinston, K. Knezevic, M. F.T.R. de Bruijn, N. Wilson, W. T. Nottingham, M. Peitz, F. Edenhofer, J. E. Pimanda, K. Ottersbach, et al. Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver Blood, March 15, 2008; 111(6): 3005 - 3014. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Wang, P. W. Faloon, Z. Tan, Y. Lv, P. Zhang, Y. Ge, H. Deng, and J.-W. Xiong Mouse lysocardiolipin acyltransferase controls the development of hematopoietic and endothelial lineages during in vitro embryonic stem-cell differentiation Blood, November 15, 2007; 110(10): 3601 - 3609. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Lucitti, E. A. V. Jones, C. Huang, J. Chen, S. E. Fraser, and M. E. Dickinson Vascular remodeling of the mouse yolk sac requires hemodynamic force Development, September 15, 2007; 134(18): 3317 - 3326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Khandekar, W. Brandt, Y. Zhou, S. Dagenais, T. W. Glover, N. Suzuki, R. Shimizu, M. Yamamoto, K.-C. Lim, and J. D. Engel A Gata2 intronic enhancer confers its pan-endothelia-specific regulation Development, May 1, 2007; 134(9): 1703 - 1712. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Deleuze, E. Chalhoub, R. El-Hajj, C. Dohet, M. Le Clech, P.-O. Couraud, P. Huber, and D. Mathieu TAL-1/SCL and Its Partners E47 and LMO2 Up-Regulate VE-Cadherin Expression in Endothelial Cells Mol. Cell. Biol., April 1, 2007; 27(7): 2687 - 2697. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. Patterson, M. Gering, C. E. Eckfeldt, A. R. Green, C. M. Verfaillie, S. C. Ekker, and R. Patient The transcription factors Scl and Lmo2 act together during development of the hemangioblast in zebrafish Blood, March 15, 2007; 109(6): 2389 - 2398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Y. I. Chan, G. A. Follows, G. Lacaud, J. E. Pimanda, J.-R. Landry, S. Kinston, K. Knezevic, S. Piltz, I. J. Donaldson, L. Gambardella, et al. The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl-/- phenotype Blood, March 1, 2007; 109(5): 1908 - 1916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. McCormack, M. A. Hall, S. M. Schoenwaelder, Q. Zhao, S. Ellis, J. A. Prentice, A. J. Clarke, N. J. Slater, J. M. Salmon, S. P. Jackson, et al. A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis Blood, October 1, 2006; 108(7): 2248 - 2256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Li, J.-W. Xiong, C. S. Shelley, H. Park, and M. A. Arnaout The transcription factor ZBP-89 controls generation of the hematopoietic lineage in zebrafish and mouse embryonic stem cells Development, September 15, 2006; 133(18): 3641 - 3650. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hamik, B. Wang, and M. K. Jain Transcriptional Regulators of Angiogenesis Arterioscler. Thromb. Vasc. Biol., September 1, 2006; 26(9): 1936 - 1947. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Umeda, T. Heike, M. Yoshimoto, G. Shinoda, M. Shiota, H. Suemori, H. Y. Luo, D. H. K. Chui, R. Torii, M. Shibuya, et al. Identification and Characterization of Hemoangiogenic Progenitors During Cynomolgus Monkey Embryonic Stem Cell Differentiation Stem Cells, May 1, 2006; 24(5): 1348 - 1358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Pimanda, L. Silberstein, M. Dominici, B. Dekel, M. Bowen, S. Oldham, A. Kallianpur, S. J. Brandt, D. Tannahill, B. Gottgens, et al. Transcriptional Link between Blood and Bone: the Stem Cell Leukemia Gene and Its +19 Stem Cell Enhancer Are Active in Bone Cells. Mol. Cell. Biol., April 1, 2006; 26(7): 2615 - 2625. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R. Asher, A. M. Cerny, and R. W. Finberg The erythrocyte viral trap: Transgenic expression of viral receptor on erythrocytes attenuates coxsackievirus B infection PNAS, September 6, 2005; 102(36): 12897 - 12902. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Silberstein, M.-J. Sanchez, M. Socolovsky, Y. Liu, G. Hoffman, S. Kinston, S. Piltz, M. Bowen, L. Gambardella, A. R. Green, et al. Transgenic Analysis of the Stem Cell Leukemia +19 Stem Cell Enhancer in Adult and Embryonic Hematopoietic and Endothelial Cells Stem Cells, September 1, 2005; 23(9): 1378 - 1388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Delabesse, S. Ogilvy, M. A. Chapman, S. G. Piltz, B. Gottgens, and A. R. Green Transcriptional Regulation of the SCL Locus: Identification of an Enhancer That Targets the Primitive Erythroid Lineage In Vivo Mol. Cell. Biol., June 15, 2005; 25(12): 5215 - 5225. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Ruppel, D. Willison, H. Kataoka, A. Wang, Y.-W. Zheng, I. Cornelissen, L. Yin, S. M. Xu, and S. R. Coughlin Essential role for G{alpha}13 in endothelial cells during embryonic development PNAS, June 7, 2005; 102(23): 8281 - 8286. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. D'Souza, A. G. Elefanty, and G. Keller SCL/Tal-1 is essential for hematopoietic commitment of the hemangioblast but not for its development Blood, May 15, 2005; 105(10): 3862 - 3870. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. Schlaeger, H. K. A. Mikkola, C. Gekas, H. B. Helgadottir, and S. H. Orkin Tie2Cre-mediated gene ablation defines the stem-cell leukemia gene (SCL/tal1)-dependent window during hematopoietic stem-cell development Blood, May 15, 2005; 105(10): 3871 - 3874. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. W.M. van Hinsbergh and T. J. Rabelink FGFR1 and the Bloodline of the Vasculature Arterioscler. Thromb. Vasc. Biol., May 1, 2005; 25(5): 883 - 886. [Full Text] [PDF]
|
|
|
|
|
|
E. Dzierzak Scl in the zebrafish: a simple (?) twist of fate Blood, May 1, 2005; 105(9): 3391 - 3392. [Full Text] [PDF]
|
|
|
|
|
|
L. J. Patterson, M. Gering, and R. Patient Scl is required for dorsal aorta as well as blood formation in zebrafish embryos Blood, May 1, 2005; 105(9): 3502 - 3511. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Ramirez-Bergeron, A. Runge, K. D. C. Dahl, H. J. Fehling, G. Keller, and M. C. Simon Hypoxia affects mesoderm and enhances hemangioblast specification during early development Development, September 15, 2004; 131(18): 4623 - 4634. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Masino, T. D. Gallardo, C. A. Wilcox, E. N. Olson, R. S. Williams, and D. J. Garry Transcriptional Regulation of Cardiac Progenitor Cell Populations Circ. Res., August 20, 2004; 95(4): 389 - 397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Park, I. Afrikanova, Y. S. Chung, W. J. Zhang, E. Arentson, G. h. Fong, A. Rosendahl, and K. Choi A hierarchical order of factors in the generation of FLK1- and SCL-expressing hematopoietic and endothelial progenitors from embryonic stem cells Development, June 1, 2004; 131(11): 2749 - 2762. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. S. Moore The "stem cell leukemia" gene: what's in a name? Blood, May 1, 2004; 103(9): 3249 - 3250. [Full Text] [PDF]
|
|
|
|
|
|
N. Koibuchi, Y. Kaneda, Y. Taniyama, K. Matsumoto, T. Nakamura, T. Ogihara, and R. Morishita Essential role of HGF (hepatocyte growth factor) in blood formation in Xenopus Blood, May 1, 2004; 103(9): 3320 - 3325. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Gottgens, C. Broccardo, M.-J. Sanchez, S. Deveaux, G. Murphy, J. R. Gothert, E. Kotsopoulou, S. Kinston, L. Delaney, S. Piltz, et al. The scl +18/19 Stem Cell Enhancer Is Not Required for Hematopoiesis: Identification of a 5' Bifunctional Hematopoietic-Endothelial Enhancer Bound by Fli-1 and Elf-1 Mol. Cell. Biol., March 1, 2004; 24(5): 1870 - 1883. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Lazrak, V. Deleuze, D. Noel, D. Haouzi, E. Chalhoub, C. Dohet, I. Robbins, and D. Mathieu The bHLH TAL-1/SCL regulates endothelial cell migration and morphogenesis J. Cell Sci., March 1, 2004; 117(7): 1161 - 1171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Yoshitomi and K. S. Zaret Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a Development, February 15, 2004; 131(4): 807 - 817. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Martin, R. Lahlil, A. Damert, L. Miquerol, A. Nagy, G. Keller, and T. Hoang SCL interacts with VEGF to suppress apoptosis at the onset of hematopoiesis Development, February 1, 2004; 131(3): 693 - 702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gering, Y. Yamada, T. H. Rabbitts, and R. K. Patient Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1 Development, December 22, 2003; 130(25): 6187 - 6199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Cairns, E. Moroni, E. Levantini, A. Giorgetti, F. G. Klinger, S. Ronzoni, L. Tatangelo, C. Tiveron, M. De Felici, S. Dolci, et al. Kit regulatory elements required for expression in developing hematopoietic and germ cell lineages Blood, December 1, 2003; 102(12): 3954 - 3962. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. G. Katz, A. Williams, J. Yang, Y. Fujiwara, A. P. Tsang, J. A. Epstein, and S. H. Orkin Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development PNAS, November 25, 2003; 100(24): 14030 - 14035. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. M. Nadin, M. A. Goodell, and K. K. Hirschi Phenotype and hematopoietic potential of side population cells throughout embryonic development Blood, October 1, 2003; 102(7): 2436 - 2443. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Chan, S. A. Johnson, Y. Li, M. C. Yoder, and G.-S. Feng A definitive role of Shp-2 tyrosine phosphatase in mediating embryonic stem cell differentiation and hematopoiesis Blood, September 15, 2003; 102(6): 2074 - 2080. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Byrd, S. Becker, P. Maye, R. Narasimhaiah, B. St-Jacques, X. Zhang, J. McMahon, A. McMahon, and L. Grabel Hedgehog is required for murine yolk sac angiogenesis Development, March 3, 2003; 129(2): 361 - 372. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. McGrath, A. D. Koniski, J. Malik, and J. Palis Circulation is established in a stepwise pattern in the mammalian embryo Blood, March 1, 2003; 101(5): 1669 - 1675. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Elvert, A. Kappel, R. Heidenreich, U. Englmeier, S. Lanz, T. Acker, M. Rauter, K. Plate, M. Sieweke, G. Breier, et al. Cooperative Interaction of Hypoxia-inducible Factor-2alpha (HIF-2alpha ) and Ets-1 in the Transcriptional Activation of Vascular Endothelial Growth Factor Receptor-2 (Flk-1) J. Biol. Chem., February 21, 2003; 278(9): 7520 - 7530. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Hall, D. J. Curtis, D. Metcalf, A. G. Elefanty, K. Sourris, L. Robb, J. R. Gothert, S. M. Jane, and C. G. Begley The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12 PNAS, February 4, 2003; 100(3): 992 - 997. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kubo and K. Alitalo The bloody fate of endothelial stem cells Genes & Dev., February 1, 2003; 17(3): 322 - 329. [Full Text] [PDF]
|
|
|
|
|
|
M. Ema, P. Faloon, W. J. Zhang, M. Hirashima, T. Reid, W. L. Stanford, S. Orkin, K. Choi, and J. Rossant Combinatorial effects of Flk1 and Tal1 on vascular and hematopoietic development in the mouse Genes & Dev., February 1, 2003; 17(3): 380 - 393. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. K. A. Mikkola, Y. Fujiwara, T. M. Schlaeger, D. Traver, and S. H. Orkin Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo Blood, January 15, 2003; 101(2): 508 - 516. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Lacaud, L. Gore, M. Kennedy, V. Kouskoff, P. Kingsley, C. Hogan, L. Carlsson, N. Speck, J. Palis, and G. Keller Runx1 is essential for hematopoietic commitment at the hemangioblast stage of development in vitro Blood, June 28, 2002; 100(2): 458 - 466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Tang, J. L. Arbiser, and S. J. Brandt Phosphorylation by Mitogen-activated Protein Kinase Mediates the Hypoxia-induced Turnover of the TAL1/SCL Transcription Factor in Endothelial Cells J. Biol. Chem., May 17, 2002; 277(21): 18365 - 18372. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Sinclair, A. J. Bench, A. J. C. Bloor, J. Li, B. Gottgens, M. L. Stanley, J. Miller, S. Piltz, S. Hunter, E. P. Nacheva, et al. Rescue of the lethal scl-/- phenotype by the human SCL locus Blood, May 13, 2002; 99(11): 3931 - 3938. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Gottgens, L. M. Barton, M. A. Chapman, A. M. Sinclair, B. Knudsen, D. Grafham, J. G.R. Gilbert, J. Rogers, D. R. Bentley, and A. R. Green Transcriptional Regulation of the Stem Cell Leukemia Gene (SCL) --- Comparative Analysis of Five Vertebrate SCL Loci Genome Res., May 1, 2002; 12(5): 749 - 759. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Cambot, S. Aresta, B. Kahn-Perles, J. de Gunzburg, and P.-H. Romeo Human Immune Associated Nucleotide 1: a member of a new guanosine triphosphatase family expressed in resting T and B cells Blood, May 1, 2002; 99(9): 3293 - 3301. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. A. Blobel CBP and p300: versatile coregulators with important roles in hematopoietic gene expression J. Leukoc. Biol., April 1, 2002; 71(4): 545 - 556. [Full Text] [PDF]
|
|
|
|
|
|
K.-i. Minehata, Y.-s. Mukouyama, T. Sekiguchi, T. Hara, and A. Miyajima Macrophage colony stimulating factor modulates the development of hematopoiesis by stimulating the differentiation of endothelial cells in the AGM region Blood, April 1, 2002; 99(7): 2360 - 2368. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Falini and D. Y. Mason Proteins encoded by genes involved in chromosomal alterations in lymphoma and leukemia: clinical value of their detection by immunocytochemistry Blood, January 15, 2002; 99(2): 409 - 426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. S. Chung, W. J. Zhang, E. Arentson, P. D. Kingsley, J. Palis, and K. Choi Lineage analysis of the hemangioblast as defined by FLK1 and SCL expression Development, January 12, 2002; 129(23): 5511 - 5520. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-J. Sanchez, E.-O. Bockamp, J. Miller, L. Gambardella, and A. R. Green Selective rescue of early haematopoietic progenitors in Scl-/- mice by expressing Scl under the control of a stem cell enhancer Development, December 1, 2001; 128(23): 4815 - 4827. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Aitsebaomo, M. L. Kingsley-Kallesen, Y. Wu, T. Quertermous, and C. Patterson Vezf1/DB1 Is an Endothelial Cell-specific Transcription Factor That Regulates Expression of the Endothelin-1 Promoter J. Biol. Chem., October 12, 2001; 276(42): 39197 - 39205. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Jasinski, P. Keller, Y. Fujiwara, S. H. Orkin, and M. Bessler GATA1-Cre mediates Piga gene inactivation in the erythroid/megakaryocytic lineage and leads to circulating red cells with a partial deficiency in glycosyl phosphatidylinositol-linked proteins (paroxysmal nocturnal hemoglobinuria type II cells) Blood, October 1, 2001; 98(7): 2248 - 2255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
