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Vol. 12, No. 5, pp. 621-626, March 1, 1998
1 Division of Hematology/Oncology,
Children's Hospital, Department of Pediatrics and Howard Hughes
Medical Institute, Harvard Medical School, Boston, Massachusetts 02115 USA;
2 Division of Health Sciences and Technology,
Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts
02139 USA;
3 Ludwig Institute for Cancer Research, PO Royal
Melbourne Hospital, Victoria, Australia;
4 Institute of
Neuroscience, University of Oregon, Eugene, Oregon 97403 USA
SCL/Tal-1 is a transcription factor necessary for
hematopoietic stem cell differentiation. Although SCL is also
expressed in endothelial and neural progenitors, SCL function
in these cells remains unknown. In the zebrafish mutant cloche
(clo), SCL expression is nearly abolished in
hematopoietic and vascular tissues. Correspondingly, it was shown
previously that clo fails to differentiate blood and
angioblasts. Genetic analysis demonstrates that the clo
mutation is not linked to the SCL locus. Forced expression of
SCL in clo embryos rescues the blood and vascular
defects, suggesting that SCL acts downstream of clo to
specify hematopoietic and vascular differentiation.
[Key Words: SCL/Tal-1; clo; zebrafish; hematopoiesis; vasculogenesis]
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