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Vol. 13, No. 10, pp. 1289-1296, May 15, 1999
Department of Molecular and Cell Biology, University of California,
Berkeley, Berkeley, California 94720 USA
In eukaryotes the sites for the initiation of chromosomal DNA
replication are believed to be determined in part by the binding of a
heteromeric origin recognition complex (ORC) to DNA. We have cloned the
genes encoding the subunits of the Drosophila ORC. Each of the
genes is unique and can be mapped to discrete chromosomal locations
implying that the pattern and developmental regulation of origin usage
in Drosophila is not regulated solely by a large family of
different ORC proteins. The six-subunit ORC can be reconstituted with
recombinant proteins into a complex that restores DNA replication in
ORC-depleted Drosophila or Xenopus egg extracts.
[Key Words: DNA replication; ORC; Drosophila; gene mapping]
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