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Vol. 13, No. 12, pp. 1513-1518, June 15, 1999
Center for RNA Molecular Biology, Department of Molecular Biology
and Microbiology, Case Western Reserve University School of Medicine,
Cleveland, Ohio 44106 USA
Serine/arginine-rich splicing factors (SR proteins)
are substrates for serine phosphorylation that can regulate SR protein function. We have observed gross changes in SR protein phosphorylation during early development coincident with major zygotic gene activation in the nematode Ascaris lumbricoides. These differences
correlate with large-scale changes in SR protein activity in promoting
both trans- and cis-splicing. Importantly, inactive
early stage extracts can be made splicing competent on addition of
later stage SR proteins. These data suggest that changes in SR protein
phosphorylation have a role in the activation of pre-mRNA splicing
during early development.
[Key Words: SR protein; splicing factor; phosphorylation; development]
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