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Vol. 13, No. 13, pp. 1647-1652, July 1, 1999
Department of Molecular, Cellular, and Developmental Biology,
University of Colorado at Boulder, Boulder, Colorado 80309-0347 USA
NeuroD, a bHLH transcription factor, is implicated in
differentiation of neurons and pancreatic 
cells. NeuroD-null mice die shortly after birth due to severe neonatal diabetes. To examine if
there is postnatal neuronal phenotype in these mice, we rescued them
from neonatal lethality by introducing a transgene encoding the mouse
neuroD gene under the insulin promoter. These mice survive to
adulthood but display severe neurological phenotype due to neuronal
deficit in the granule layers of the cerebellum and hippocampus. We
show here that NeuroD is required for these postnatally generated microneurons to undergo proper differentiation, the absence of which
results in cell death.
[Key Words: NeuroD; neuronal differentiation; microneuron; postnatal neurogenesis; cerebellum; hippocampus]
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