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Vol. 13, No. 13, pp. 1754-1761, July 1, 1999
Centro de Biología Molecular Severo Ochoa, Consejo Superior de
Investigaciones (C.S.I.C.) Científicas and Universidad
Antónoma de Madrid, Cantoblanco, 28049 Madrid, Spain
The Iroquois complex (Iro-C) homeodomain proteins allow cells at the
proximal part of the Drosophila imaginal wing disc to form
mesothoracic body wall (notum). Cells lacking these proteins form wing
hinge structures instead (tegula and axillary sclerites). Moreover, the
mutant cells impose on neighboring wild-type cells more distal
developmental fates, like lateral notum or wing hinge. These findings
support a tergal phylogenetic origin for the most proximal part of the
wing and provide evidence for a novel pattern organizing center at the
border between the apposed notum (Iro-C-expressing) and hinge
(Iro-C-nonexpressing) cells. This border is not a cell lineage
restriction boundary.
[Key Words: Iroquois complex; imaginal wing disc; thorax development; Drosophila]
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