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Vol. 13, No. 15, pp. 1918-1923, August 1, 1999
1 Howard Hughes Medical Institute, 2 Department
of Genetics, 3 Department of Pathology, Brigham and Women's
Hospital, Harvard Medical School, Boston, Massachusetts 02115 USA;
4 National Institutes of Health, National Institute of Allergy
and Infectious Diseases, Bethesda, Maryland 20892-0460 USA
The mammalian Daxx gene has been identified in a diverse
set of yeast interaction trap experiments. Although a facilitating role
for Daxx in Fas-induced apoptosis has been suggested, Daxx's physiologic function remains unknown. To elucidate the in vivo role of
Daxx, we have generated Daxx-deficient mice. Surprisingly, rather than
a hyperproliferative disorder expected from the loss of a pro-apoptotic
gene, mutation of Daxx results in extensive apoptosis and embryonic
lethality. These findings argue against a role for Daxx in promoting
Fas-induced cell death and suggest that Daxx either directly or
indirectly suppresses apoptosis in the early embryo.
[Key Words: Daxx; yeast two-hybrid; apoptosis; Fas]
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