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Vol. 13, No. 15, pp. 2017-2027, August 1, 1999
Department of Plant and Microbial Biology, University of California,
Berkeley, California 94720 USA; and U.S. Department of
Agriculture/Agricultural Research Service, Plant Gene
Expression Center, Albany, California 94710 USA
The phytochrome family of photoreceptors has a well-defined role in
regulating gene expression in response to informational light signals.
Little is known, however, of the early steps of phytochrome signal
transduction. Here we describe a new Arabidopsis mutant,
far1 (far-red-impaired response), which has
reduced responsiveness to continuous far-red light, but responds
normally to other light wavelengths. This phenotype implies a specific
requirement for FAR1 in phyA signal transduction. The far1
locus maps to the south arm of chromosome 4, and is not allelic to
photomorphogenic loci identified previously. All five far1
alleles isolated have single nucleotide substitutions that introduce
stop codons in a single ORF. The FAR1 gene encodes a protein
with no significant sequence similarity to any proteins of known
function. The FAR1 protein contains a predicted nuclear localization
signal and is targeted to the nucleus in transient transfection assays.
This result supports an emerging view that early steps in phytochrome
signaling may be centered in the nucleus. The FAR1 gene defines
a new multigene family, which consists of at least four genes in
Arabidopsis. This observation raises the possibility of
redundancy in the phyA-signaling pathway, which could account for the
incomplete block of phyA signaling observed in the far1 mutant.
[Key Words: Signal transduction; phytochrome; far-red; nuclear; Arabidopsis]
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