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Vol. 13, No. 19, pp. 2484-2489, October 1, 1999
Department of Biological Chemistry and Molecular Pharmacology,
Harvard Medical School, Boston, Massachusetts 02115 USA
Many questions remain concerning the role of TFIID TBP-associated
factors (TAFs) in transcription, including whether TAFs are required at
most or only a small subset of promoters. It was shown previously that
three histone-like TAFs are broadly required for transcription, but
interpretation of this observation is complicated because these
proteins are components of both TFIID and the SAGA histone
acetyltransferase complex. Here we show that mutations in the yeast
TFIID-specific protein Taf40 lead to a general cessation of
transcription, even in the presence of excess TBP, suggesting that the
TFIID complex is required at most promoters in vivo.
[Key Words: TAFS; promoters; TFIID; TAF40; transcription]
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