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Vol. 13, No. 3, pp. 253-258, February 1, 1999
1 Department of Genetics, Harvard Medical School, Boston,
Massachusetts 02115 USA; 2 Department of Biochemistry,
University of Iowa, Iowa City, Iowa 52242 USA
Transvection can cause the expression of a gene to be sensitive to
the proximity of a homolog. It can account for many cases of intragenic
complementation at the Drosophila yellow gene, where one mode
of transvection involves the action of enhancers in trans on a
promoter present on a separate chromosome. Our goal was to identify
cis-acting elements that regulate the trans action of enhancers. Using gene replacement, we altered two core promoter elements at yellow and tested the resulting alleles for their ability to support transvection. We found that the TATA box and initiator element can regulate transvection.
[Key Words: Enhancer; pairing; promoter; transcription; transvection; yellow]
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