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Vol. 13, No. 3, pp. 320-333, February 1, 1999
Research Institute of Molecular Pathology (IMP),
A-1030 Vienna, Austria
Sister chromatid cohesion is crucial for chromosome segregation
during mitosis. Loss of cohesion very possibly triggers sister separation at the metaphase 
anaphase transition. This process depends on the destruction of anaphase inhibitory proteins like Pds1p
(Cut2p), which is thought to liberate a sister-separating protein Esp1p
(Cut1p). By looking for mutants that separate sister centromeres in the
presence of Pds1p, this and a previous study have identified six
proteins essential for establishing or maintaining sister chromatid
cohesion. Four of these proteins, Scc1p, Scc3p, Smc1p, and Smc3p, are
subunits of a `Cohesin' complex that binds chromosomes from late
G1 until the onset of anaphase. The fifth protein, Scc2p, is
not a stoichiometric Cohesin subunit but it is required for Cohesin's
association with chromosomes. The sixth protein, Eco1p(Ctf7p), is not a
Cohesin subunit. It is necessary for the establishment of cohesion
during DNA replication but not for its maintenance during G2
and M phases.
[Key Words: ECO1; Cohesin complex; SCC2; SCC3; establishment of cohesion; sister chromatid separation]
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