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Vol. 13, No. 4, pp. 382-387, February 15, 1999
B that blocks TNF
-induced apoptosis
1 Center for Advanced Biotechnology and Medicine,
2 Graduate Program in Biochemistry and Molecular Biology, Bcl-2-family proteins are key regulators of the apoptotic
response. Here, we demonstrate that the pro-survival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF- [Key Words:
Rel; NF-
B.
We show that bfl-1 gene expression is dependent on NF-B
activity and that it can substitute for NF-B to suppress
TNF
-induced apoptosis. bfl-1 promoter analysis identified an
NF-B site responsible for its Rel/NF-B-dependent
induction. The expression of bfl-1 in immune tissues supports
the protective role of NF-B in the immune system. The activation of
Bfl-1 may be the means by which NF-B functions in oncogenesis and
promotes cell resistance to anti-cancer therapy.
B; Bfl-1; A1; TNF; apoptosis]
GENES & DEVELOPMENT 13:382-387 © 1999 by Cold Spring Harbor Laboratory Press ISSN 0890-9369/99 $5.00
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