![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 13, No. 6, pp. 649-654, March 15, 1999
Sonderforschungsbereich (SFB) Junior Group, Institute for Human
Genetics, University of Göttingen, c/o
Max-Planck-Institute (MPI) for Biophysical Chemistry, Am Fassberg,
37077 Göttingen, Germany
The homeobox gene sine oculis (so) is essential
for visual system formation in Drosophila. A vertebrate member
of the so/Six gene family, Six3, is expressed in the
developing eye and forebrain. Injection of Six3 RNA into medaka
fish embryos causes ectopic Pax6 and Rx2 expression in
midbrain and cerebellum, resulting in the formation of ectopic retinal
primordia. Injected mouse Six3 RNA initiates ectopic expression
of endogenous medaka Six3, uncovering a feedback control of
Six3 expression. Initiation of ectopic retina formation reveals
a pivotal role for Six3 in vertebrate retina development and
hints at a conserved regulatory network underlying vertebrate and
invertebrate eye development.
[Key Words: Six homeobox gene; eye development; evolution; medaka]
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  I. Appolloni, F. Calzolari, G. Corte, R. Perris, and P. Malatesta Six3 Controls the Neural Progenitor Status in the Murine CNS Cereb Cortex, March 1, 2008; 18(3): 553 - 562. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Coiffier, B. Charroux, and S. Kerridge Common functions of central and posterior Hox genes for the repression of head in the trunk of Drosophila Development, January 15, 2008; 135(2): 291 - 300. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Grabher, A. Cliffe, K. Miura, J. Hayflick, R. Pepperkok, P. Rorth, and J. Wittbrodt Birth and life of tissue macrophages and their migration in embryogenesis and inflammation in medaka J. Leukoc. Biol., January 1, 2007; 81(1): 263 - 271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Peng and M. Westerfield Lhx5 promotes forebrain development and activates transcription of secreted Wnt antagonists Development, August 15, 2006; 133(16): 3191 - 3200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Gestri, M. Carl, I. Appolloni, S. W. Wilson, G. Barsacchi, and M. Andreazzoli Six3 functions in anterior neural plate specification by promoting cell proliferation and inhibiting Bmp4 expression Development, May 15, 2005; 132(10): 2401 - 2413. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Azuma, K. Tadokoro, A. Asaka, M. Yamada, Y. Yamaguchi, H. Handa, S. Matsushima, T. Watanabe, Y. Kida, T. Ogura, et al. Transdifferentiation of the retinal pigment epithelia to the neural retina by transfer of the Pax6 transcriptional factor Hum. Mol. Genet., April 15, 2005; 14(8): 1059 - 1068. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ozaki, K. Nakamura, J.-i. Funahashi, K. Ikeda, G. Yamada, H. Tokano, H.-o. Okamura, K. Kitamura, S. Muto, H. Kotaki, et al. Six1 controls patterning of the mouse otic vesicle Development, February 1, 2004; 131(3): 551 - 562. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Zuber, G. Gestri, A. S. Viczian, G. Barsacchi, and W. A. Harris Specification of the vertebrate eye by a network of eye field transcription factors Development, November 1, 2003; 130(21): 5155 - 5167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Zhu, M. A. Dyer, M. Uchikawa, H. Kondoh, O. V. Lagutin, and G. Oliver Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors Development, March 8, 2003; 129(12): 2835 - 2849. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lopez-Rios, K. Tessmar, F. Loosli, J. Wittbrodt, and P. Bovolenta Six3 and Six6 activity is modulated by members of the groucho family Development, January 1, 2003; 130(1): 185 - 195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Carl, F. Loosli, and J. Wittbrodt Six3 inactivation reveals its essential role for the formation and patterning of the vertebrate eye Development, September 1, 2002; 129(17): 4057 - 4063. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Goudreau, P. Petrou, L. W. Reneker, J. Graw, J. Loster, and P. Gruss Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype PNAS, June 25, 2002; 99(13): 8719 - 8724. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Arendt, K. Tessmar, M.-I. M. de Campos-Baptista, A. Dorresteijn, and J. Wittbrodt Development of pigment-cup eyes in the polychaete Platynereis dumerilii and evolutionary conservation of larval eyes in Bilateria Development, January 3, 2002; 129(5): 1143 - 1154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Kobayashi, M. Kobayashi, K. Matsumoto, T. Ogura, M. Nakafuku, and K. Shimamura Early subdivisions in the neural plate define distinct competence for inductive signals Development, January 1, 2002; 129(1): 83 - 93. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Bernier, W. Vukovich, L. Neidhardt, B. G. Herrmann, and P. Gruss Isolation and characterization of a downstream target of Pax6 in the mammalian retinal primordium Development, October 15, 2001; 128(20): 3987 - 3994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Loosli, S. Winkler, C. Burgtorf, E. Wurmbach, W. Ansorge, T. Henrich, C. Grabher, D. Arendt, M. Carl, A. Krone, et al. Medaka eyeless is the key factor linking retinal determination and eye growth Development, October 15, 2001; 128(20): 4035 - 4044. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ozaki, Y. Watanabe, K. Takahashi, K. Kitamura, A. Tanaka, K. Urase, T. Momoi, K. Sudo, J. Sakagami, M. Asano, et al. Six4, a Putative myogenin Gene Regulator, Is Not Essential for Mouse Embryonal Development Mol. Cell. Biol., May 15, 2001; 21(10): 3343 - 3350. [Abstract] [Full Text]
|
|
|
|
|
|
J. T. Rasmussen, M. A. Deardorff, C. Tan, M. S. Rao, P. S. Klein, and M. L. Vetter Regulation of eye development by frizzled signaling in Xenopus PNAS, March 27, 2001; 98(7): 3861 - 3866. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Davis, W. Shen, Y. I. Sandler, M. Amoui, P. Purcell, R. Maas, C.-N. Ou, H. Vogel, A. L. Beaudet, and G. Mardon Dach1 Mutant Mice Bear No Gross Abnormalities in Eye, Limb, and Brain Development and Exhibit Postnatal Lethality Mol. Cell. Biol., March 1, 2001; 21(5): 1484 - 1490. [Abstract] [Full Text]
|
|
|
|
 |
|
 H. B. Sarnat Molecular Genetic Classification of Central Nervous System Malformations J Child Neurol, October 1, 2000; 15(10): 675 - 687. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Blixt, M. Mahlapuu, M. Aitola, M. Pelto-Huikko, S. Enerbäck, and P. Carlsson A forkhead gene, FoxE3, is essential for lens epithelial proliferation and closure of the lens vesicle Genes & Dev., January 15, 2000; 14(2): 245 - 254. [Abstract] [Full Text]
|
|
|
|
|
|
A Noveen, A Daniel, and V Hartenstein Early development of the Drosophila mushroom body: the roles of eyeless and dachshund Development, January 8, 2000; 127(16): 3475 - 3488. [Abstract] [PDF]
|
|
|
|
|
|
M Seimiya and W. Gehring The Drosophila homeobox gene optix is capable of inducing ectopic eyes by an eyeless-independent mechanism Development, January 5, 2000; 127(9): 1879 - 1886. [Abstract] [PDF]
|
|
|
|
|
|
S Winkler, F Loosli, T Henrich, Y Wakamatsu, and J Wittbrodt The conditional medaka mutation eyeless uncouples patterning and morphogenesis of the eye Development, January 5, 2000; 127(9): 1911 - 1919. [Abstract] [PDF]
|
|
|
|
|
|
F. Relaix and M. Buckingham From insect eye to vertebrate muscle: redeployment of a regulatory network Genes & Dev., December 15, 1999; 13(24): 3171 - 3178. [Full Text]
|
|
|
|
|
|
H. Ohto, S. Kamada, K. Tago, S.-I. Tominaga, H. Ozaki, S. Sato, and K. Kawakami Cooperation of Six and Eya in Activation of Their Target Genes through Nuclear Translocation of Eya Mol. Cell. Biol., October 1, 1999; 19(10): 6815 - 6824. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Carl and J Wittbrodt Graded interference with FGF signalling reveals its dorsoventral asymmetry at the mid-hindbrain boundary Development, January 12, 1999; 126(24): 5659 - 5667. [Abstract] [PDF]
|
|
|
|
|
|
R. Chow, C. Altmann, R. Lang, and A Hemmati-Brivanlou Pax6 induces ectopic eyes in a vertebrate Development, January 10, 1999; 126(19): 4213 - 4222. [Abstract] [PDF]
|
|
|
|
|
|
Y. Onuma, S. Takahashi, M. Asashima, S. Kurata, and W. J. Gehring Conservation of Pax 6 function and upstream activation by Notch signaling in eye development of frogs and flies PNAS, February 19, 2002; 99(4): 2020 - 2025. [Abstract] [Full Text] [PDF]
|
|
