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Vol. 13, No. 7, pp. 827-840, April 1, 1999
1 Department of Biology, We isolated mutations in Drosophila E2F and DP that
affect chorion gene amplification and ORC2 localization in the follicle cells. In the follicle cells of the ovary, the ORC2 protein is localized throughout the follicle cell nuclei when they are undergoing polyploid genomic replication, and its levels appear constant in both S
and G phases. In contrast, when genomic replication ceases and specific
regions amplify, ORC2 is present solely at the amplifying loci.
Mutations in the DNA-binding domains of dE2F or dDP
reduce amplification, and in these mutants specific localization of
ORC2 to amplification loci is lost. Interestingly, a dE2F
mutant predicted to lack the carboxy-terminal transcriptional
activation and RB-binding domain does not abolish ORC2 localization and
shows premature chorion amplification. The effect of the mutations in the heterodimer subunits suggests that E2F controls not only the onset
of S phase but also origin activity within S phase.
[Key Words:
DNA replication; ORC; E2F; DP; Drosophila; oogenesis]
GENES & DEVELOPMENT 13:827-840 © 1999 by Cold Spring Harbor Laboratory Press ISSN 0890-9369/99 $5.00
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