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Vol. 13, No. 9, pp. 1073-1078, May 1, 1999
Department of Microbiology, Columbia University,
College of Physicians and Surgeons, New York, New York 10032 USA; 1 Department of Microbiology, University of
Virginia, Charlottesville, Virginia 22908 USA
The c-Myb transcription factor is important for fetal
hematopoiesis and has been proposed to mediate later stages of
lymphocyte development. Using homozygous null
c-Myb/Rag1 chimeric mice, we have determined that
c-Myb plays an important role in the differentiation of macrophages and
lymphocytes from precursor stem cells. We also determine that deletion
of c-Myb leads to a complete block in early T cell development just
before the oligopotent thymocyte matures into the definitive T cell
precursor. These data indicate that c-Myb plays an important role at
multiple stages of hematopoiesis and is required at an early stage of T
cell development.
[Key Words: c-Myb; T cell development; lineage commitment]
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