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Vol. 14, No. 10, pp. 1181-1185, May 15, 2000
Cutaneous Biology Research Center, Massachusetts General Hospital
and Harvard Medical School, Charlestown, Massachusetts 02129 USA
The formation of the hair follicle and its cyclical growth,
quiescence, and regeneration depend on reciprocal signaling between its
epidermal and dermal components. The dermal organizing center, the
dermal papilla (DP), regulates development of the epidermal follicle
and is dependent on signals from the epidermis for its development and
maintenance. GFP specifically expressed in DP cells of a transgenic
mouse was used to purify this population and study the signals required
to maintain it. We demonstrate that specific Wnts, but not Sonic
hedgehog (Shh), maintain anagen-phase gene expression in vitro and hair
inductive activity in a skin reconstitution assay.
[Key Words: Wnt signaling; epithelial-mesenchymal interactions; dermal papilla; cell purification]
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