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Vol. 14, No. 11, pp. 1308-1312, June 1, 2000
1 University of Konstanz, Department of Biology, 78457 Konstanz, Federal Republic of Germany; 2 Protein Interaction
Laboratory, University of Southern Denmark, DK-5230 Odense M, Denmark
The structure of chromatin regulates the genetic activity of the
underlying DNA sequence. We report here that the protein encoded by the
proto-oncogene DEK, which is involved in acute myelogenous leukemia,
induces alterations of the superhelical density of DNA in chromatin.
The change in topology is observed with chromatin but not with naked
DNA and does not involve dissociation of core histones from chromatin.
Moreover, these effects require histone H2A/H2B dimers in
addition to histone H3/H4. We additionally tested whether
the DEK protein affects DNA-utilizing processes and found that the DEK
protein substantially reduces the replication efficiency of chromatin
but not of naked DNA templates.
[Key Words: Chromatin structure; DEK; DNA topology; leukemogenesis]
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