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Vol. 14, No. 11, pp. 1313-1318, June 1, 2000
1 Departments of Molecular Genetics,
2 Pathology, and 3 Neurobiology, Amgen, Inc.,
Thousand Oaks, California 91320 USA; 4 Department of Pathology
and OB/GYN, Columbia University, College of Physicians
and Surgeons, New York, New York 10032 USA; 5 Molecular
Neurobiology Laboratory, The SALK Institute for Biological Studies, La
Jolla, California 90037 USA
We report the cloning and characterization of a new member of the
Delta family of Notch ligands, which we have named Dll4. Like
other Delta genes, Dll4 is predicted to encode a
membrane-bound ligand, characterized by an extracellular region
containing several EGF-like domains and a DSL domain required for
receptor binding. In situ analysis reveals a highly selective
expression pattern of Dll4 within the vascular endothelium. The
activity and expression of Dll4 and the known actions of other
members of this family suggest a role for Dll4 in the control
of endothelial cell biology.
[Key Words: Notch signaling pathway; endothelium]
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