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Vol. 14, No. 11, pp. 1407-1413, June 1, 2000
1 MRC Laboratory for Molecular Cell Biology and Departments
of Physiology, University College London, London WC1E 6BT, UK;
2 Department of Microbiology and Immunology and Department of
Medical Genetics, University of British Columbia, Vancouver V6T 1Z3,
Canada; 3 Department of Microbiology, La Trobe University,
Bundoora, Victoria 3083, Australia; 4 School of Biosciences,
Birmingham University, Edgbaston, Birmingham B15 2TT, UK
RasD, a Dictyostelium homolog of mammalian Ras, is
maximally expressed during the multicellular stage of development.
Normal Dictyostelium aggregates are phototactic and
thermotactic, moving towards sources of light and heat with great
sensitivity. We show that disruption of the gene for rasD
causes a near-total loss of phototaxis and thermotaxis in mutant
aggregates, without obvious effects on undirected movement. Previous
experiments had suggested important roles for RasD in development and
cell-type determination. Surprisingly, rasD
cells show
no obvious changes in these processes. These cells represent a novel
class of phototaxis mutant, and indicate a role for a Ras pathway in
the connections between stimuli and coordinated cell movement.
[Key Words: Phototaxis; Dictyostelium; oncogenes; Ras; small GTPases]
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