![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 14, No. 13, pp. 1678-1690, July 1, 2000
Max Planck-Institut für Entwicklungsbiologie, D-72076
Tübingen, Germany
Somitogenesis has been linked both to a molecular clock that
controls the oscillation of gene expression in the presomitic mesoderm
(PSM) and to Notch pathway signaling. The oscillator, or clock,
is thought to create a prepattern of stripes of gene expression that
regulates the activity of the Notch pathway that subsequently
directs somite border formation. Here, we report that the zebrafish
gene after eight (aei) that is required for both
somitogenesis and neurogenesis encodes the Notch ligand DeltaD. Additional analysis revealed that stripes of her1 expression
oscillate within the PSM and that aei/DeltaD
signaling is required for this oscillation.
aei/DeltaD expression does not oscillate,
indicating that the activity of the Notch pathway upstream of
her1 may function within the oscillator itself. Moreover, we
found that her1 stripes are expressed in the anlage of
consecutive somites, indicating that its expression pattern is not
pair-rule. Analysis of her1 expression in
aei/DeltaD, fused somites (fss),
and aei;fss embryos uncovered a wave-front activity that is
capable of continually inducing her1 expression de novo in the
anterior PSM in the absence of the oscillation of her1. The
wave-front activity, in reference to the clock and wave-front model, is
defined as such because it interacts with the oscillator-derived
pattern in the anterior PSM and is required for somite morphogenesis.
This wave-front activity is blocked in embryos mutant for fss
but not aei/DeltaD. Thus, our analysis indicates
that the smooth sequence of formation, refinement, and fading of
her1 stripes in the PSM is governed by two separate activities.
[Key Words: Somitogenesis; Delta; her1; oscillator; wave front; zebrafish]
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Kawamura, S. Koshida, and S. Takada Activator-to-Repressor Conversion of T-Box Transcription Factors by the Ripply Family of Groucho/TLE-Associated Mediators Mol. Cell. Biol., May 15, 2008; 28(10): 3236 - 3244. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Liu, J. Nie, G. Li, L. Guo, and S. T. C. Wong ZFIQ: a software package for zebrafish biology Bioinformatics, February 1, 2008; 24(3): 438 - 439. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Gohlke, W. C. Griffith, and E. M. Faustman Computational Models of Neocortical Neuronogenesis and Programmed Cell Death in the Developing Mouse, Monkey, and Human Cereb Cortex, October 1, 2007; 17(10): 2433 - 2442. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. H. Riedel-Kruse, C. Muller, and A. C. Oates Synchrony Dynamics During Initiation, Failure, and Rescue of the Segmentation Clock Science, September 28, 2007; 317(5846): 1911 - 1915. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Holley Anterior-posterior differences in vertebrate segments: specification of trunk and tail somites in the zebrafish blastula Genes & Dev., July 15, 2006; 20(14): 1831 - 1837. [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Masamizu, T. Ohtsuka, Y. Takashima, H. Nagahara, Y. Takenaka, K. Yoshikawa, H. Okamura, and R. Kageyama Real-time imaging of the somite segmentation clock: Revelation of unstable oscillators in the individual presomitic mesoderm cells PNAS, January 31, 2006; 103(5): 1313 - 1318. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Honjo and J. S. Eisen Slow muscle regulates the pattern of trunk neural crest migration in zebrafish Development, October 15, 2005; 132(20): 4461 - 4470. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-C. Park, J. Boyce, J. Shin, and B. Appel Oligodendrocyte Specification in Zebrafish Requires Notch-Regulated Cyclin-Dependent Kinase Inhibitor Function J. Neurosci., July 20, 2005; 25(29): 6836 - 6844. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kawamura, S. Koshida, H. Hijikata, T. Sakaguchi, H. Kondoh, and S. Takada Zebrafish Hairy/Enhancer of split protein links FGF signaling to cyclic gene expression in the periodic segmentation of somites Genes & Dev., May 15, 2005; 19(10): 1156 - 1161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Thorpe, G. Weidinger, and R. T. Moon Wnt/{beta}-catenin regulation of the Sp1-related transcription factor sp5l promotes tail development in zebrafish Development, April 15, 2005; 132(8): 1763 - 1772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Crosnier, N. Vargesson, S. Gschmeissner, L. Ariza-McNaughton, A. Morrison, and J. Lewis Delta-Notch signalling controls commitment to a secretory fate in the zebrafish intestine Development, March 1, 2005; 132(5): 1093 - 1104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kawahara, Y.-S. Che, R. Hanaoka, H. Takeda, and I. B. Dawid Zebrafish GADD45{beta} genes are involved in somite segmentation PNAS, January 11, 2005; 102(2): 361 - 366. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. J. Wright, J. D. Leslie, L. Ariza-McNaughton, and J. Lewis Delta proteins and MAGI proteins: an interaction of Notch ligands with intracellular scaffolding molecules and its significance for zebrafish development Development, November 15, 2004; 131(22): 5659 - 5669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hofmann, K. Schuster-Gossler, M. Watabe-Rudolph, A. Aulehla, B. G. Herrmann, and A. Gossler WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos Genes & Dev., November 15, 2004; 18(22): 2712 - 2717. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Aerne and D. Ish-Horowicz receptor tyrosine phosphatase {psi} is required for Delta/Notch signalling and cyclic gene expression in the presomitic mesoderm Development, July 15, 2004; 131(14): 3391 - 3399. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pasini, Y.-J. Jiang, and D. G. Wilkinson Two zebrafish Notch-dependent hairy/Enhancer-of-split-related genes, her6 and her4, are required to maintain the coordination of cyclic gene expression in the presomitic mesoderm Development, April 1, 2004; 131(7): 1529 - 1541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Lewis and J. S. Eisen Paraxial mesoderm specifies zebrafish primary motoneuron subtype identity Development, February 15, 2004; 131(4): 891 - 902. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Minguillon, S. Jimenez-Delgado, G. Panopoulou, and J. Garcia-Fernandez The amphioxus Hairy family: differential fate after duplication Development, December 15, 2003; 130(24): 5903 - 5914. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Takahashi, T. Inoue, A. Gossler, and Y. Saga Feedback loops comprising Dll1, Dll3 and Mesp2, and differential involvement of Psen1 are essential for rostrocaudal patterning of somites Development, September 15, 2003; 130(18): 4259 - 4268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gajewski, D. Sieger, B. Alt, C. Leve, S. Hans, C. Wolff, K. B. Rohr, and D. Tautz Anterior and posterior waves of cyclic her1 gene expression are differentially regulated in the presomitic mesoderm of zebrafish Development, September 15, 2003; 130(18): 4269 - 4278. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-C. Park and B. Appel Delta-Notch signaling regulates oligodendrocyte specification Development, August 15, 2003; 130(16): 3747 - 3755. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Geldmacher-Voss, A. M. Reugels, S. Pauls, and J. A. Campos-Ortega A 90{degrees} rotation of the mitotic spindle changes the orientation of mitoses of zebrafish neuroepithelial cells Development, August 15, 2003; 130(16): 3767 - 3780. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Bink, H. Habuchi, Z. Lele, E. Dolk, J. Joore, G.-J. Rauch, R. Geisler, S. W. Wilson, J. den Hertog, K. Kimata, et al. Heparan Sulfate 6-O-Sulfotransferase Is Essential for Muscle Development in Zebrafish J. Biol. Chem., August 15, 2003; 278(33): 31118 - 31127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Pourquie The Segmentation Clock: Converting Embryonic Time into Spatial Pattern Science, July 18, 2003; 301(5631): 328 - 330. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Bessho, H. Hirata, Y. Masamizu, and R. Kageyama Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock Genes & Dev., June 15, 2003; 17(12): 1451 - 1456. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hans and J. A. Campos-Ortega On the organisation of the regulatory region of the zebrafish deltaD gene Development, March 12, 2003; 129(20): 4773 - 4784. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Oates and R. K. Ho Hairy/E(spl)-related (Her) genes are central components of the segmentation oscillator and display redundancy with the Delta/Notch signaling pathway in the formation of anterior segmental boundaries in the zebrafish Development, March 8, 2003; 129(12): 2929 - 2946. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hirata, S. Yoshiura, T. Ohtsuka, Y. Bessho, T. Harada, K. Yoshikawa, and R. Kageyama Oscillatory Expression of the bHLH Factor Hes1 Regulated by a Negative Feedback Loop Science, October 25, 2002; 298(5594): 840 - 843. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Sato, K. Yasuda, and Y. Takahashi Morphological boundary forms by a novel inductive event mediated by Lunatic fringe and Notch during somitic segmentation Development, August 1, 2002; 129(15): 3633 - 3644. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Henry, M. K. Urban, K. K. Dill, J. P. Merlie, M. F. Page, C. B. Kimmel, and S. L. Amacher Two linked hairy/Enhancer of split-related zebrafish genes, her1 and her7, function together to refine alternating somite boundaries Development, August 1, 2002; 129(15): 3693 - 3704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Latimer, X. Dong, Y. Markov, and B. Appel Delta-Notch signaling induces hypochord development in zebrafish Development, January 6, 2002; 129(11): 2555 - 2563. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Dunwoodie, M. Clements, D. B. Sparrow, X. Sa, R. A. Conlon, and R. S. P. Beddington Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm Development, January 4, 2002; 129(7): 1795 - 1806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Holley, D. Julich, G.-J. Rauch, R. Geisler, and C. Nusslein-Volhard her1 and the notch pathway function within the oscillator mechanism that regulates zebrafish somitogenesis Development, January 3, 2002; 129(5): 1175 - 1183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Freitas, S. Rodrigues, J.-B. Charrier, M.-A. Teillet, and I. Palmeirim Evidence for medial/lateral specification and positional information within the presomitic mesoderm Development, December 15, 2001; 128(24): 5139 - 5147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sawada, M. Shinya, Y.-J. Jiang, A. Kawakami, A. Kuroiwa, and H. Takeda Fgf/MAPK signalling is a crucial positional cue in somite boundary formation Development, December 1, 2001; 128(23): 4873 - 4880. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Bessho, R. Sakata, S. Komatsu, K. Shiota, S. Yamada, and R. Kageyama Dynamic expression and essential functions of Hes7 in somite segmentation Genes & Dev., October 15, 2001; 15(20): 2642 - 2647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Topczewska, J. Topczewski, A. Shostak, T. Kume, L. Solnica-Krezel, and B. L.M. Hogan The winged helix transcription factor Foxc1a is essential for somitogenesis in zebrafish Genes & Dev., September 15, 2001; 15(18): 2483 - 2493. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Sun, C. N. Kamei, M. D. Layne, M. K. Jain, J. K. Liao, M.-E. Lee, and M. T. Chin Regulation of Myogenic Terminal Differentiation by the Hairy-related Transcription Factor CHF2 J. Biol. Chem., May 18, 2001; 276(21): 18591 - 18596. [Abstract] [Full Text] [PDF]
|
|
