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Vol. 14, No. 17, pp. 2140-2145, September 1, 2000

RESEARCH COMMUNICATION
Single mesodermal cells guide outgrowth of ectodermal tubular structures in Drosophila

Christian Wolf, and Reinhard Schuh1

Max Planck Institut für biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie, Am Fassberg, D-37077 Göttingen, Germany

The Drosophila tracheal system, a tubular network, is formed from isolated ectodermal metameres by guided branch outgrowth and branch fusion. Branch outgrowth is triggered by the localized and transient activity of Branchless (Bnl/dFGF). Here, we report the discovery of a mesodermal cell that links the leading cells of outgrowing main branches 2.5 hr before they fuse. This bridge-cell serves as an essential guidance post and needs Hunchback (Hb) activity to exert its function. The bridge-cell provides cues acting in concert with Bnl/dFGF signaling to mediate directed branch outgrowth that ultimately leads to position-specific branch fusion.

[Key Words: hunchback; FGF; tracheal system; Drosophila; guidance]

1 Corresponding author.

GENES & DEVELOPMENT 14:2140-2145 © 2000 by Cold Spring Harbor Laboratory Press  ISSN 0890-9369/00 $5.00
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