.gif?ad=16248&adview=true)
![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 14, No. 18, pp. 2358-2365, September 15, 2000
Departments of 1 Tumor Cell Biology,
2 Biochemistry, and 3 Pathology, St. Jude Children's
Research Hospital, Memphis, Tennessee 38105, USA; 4 Department
of Biochemistry, University of Tennessee, Memphis, Tennessee 38163, USA; 5 Howard Hughes Medical Institute, St. Jude
Children's Research Hospital, Memphis, Tennessee 38105, USA;
6 Department of Molecular Genetics, The University of Texas
M.D. Anderson Cancer Center, Houston, Texas 77030, USA
The p19ARF tumor suppressor antagonizes Mdm2 to induce p53-dependent cell cycle arrest. Individual TKO (triple knock out) mice nullizygous for ARF, p53, and Mdm2 develop multiple tumors at a frequency greater than those observed in animals lacking both p53
and Mdm2 or p53 alone, demonstrating that p19ARF can
act independently of the Mdm2-p53 axis in tumor surveillance. Reintroduction of ARF into TKO mouse embryo fibroblasts
(MEFs), but not into those lacking both p53 and
ARF, arrested the cell division cycle in the G1 phase.
Inhibition of the retinoblastoma protein had no effect on the ability
of ARF to arrest TKO MEFs. Thus, in the absence of Mdm2,
p19ARF interacts with other targets to inhibit cell proliferation.
[Key Words: ARF; p53; Mdm2; DMP1; tumor suppression]
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  Y. Huang, M. Wu, and H.-Y. Li Tumor Suppressor ARF Promotes Non-classic Proteasome-independent Polyubiquitination of COMMD1 J. Biol. Chem., April 25, 2008; 283(17): 11453 - 11460. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Yogev, K. Saadon, S. Anzi, K. Inoue, and E. Shaulian DNA Damage-Dependent Translocation of B23 and p19ARF Is Regulated by the Jun N-Terminal Kinase Pathway Cancer Res., March 1, 2008; 68(5): 1398 - 1406. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Paliwal, R. C. Kovi, B. Nath, Y.-W. Chen, B. C. Lewis, and S. R. Grossman The Alternative Reading Frame Tumor Suppressor Antagonizes Hypoxia-Induced Cancer Cell Migration via Interaction with the COOH-Terminal Binding Protein Corepressor Cancer Res., October 1, 2007; 67(19): 9322 - 9329. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Munoz-Fontela, M. A. Garcia, M. Collado, L. Marcos-Villar, P. Gallego, M. Esteban, and C. Rivas Control of virus infection by tumour suppressors Carcinogenesis, June 1, 2007; 28(6): 1140 - 1144. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Morton, T. Kantidakis, and R. J. White RNA polymerase III transcription is repressed in response to the tumour suppressor ARF Nucleic Acids Res., May 14, 2007; 35(9): 3046 - 3052. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Thornton, D. J. Swanson, M. N. Mary, D. Pei, A. C. Martin, S. Pounds, D. Goldowitz, and S. X. Skapek Persistent Hyperplastic Primary Vitreous Due to Somatic Mosaic Deletion of the Arf Tumor Suppressor Invest. Ophthalmol. Vis. Sci., February 1, 2007; 48(2): 491 - 499. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. S. Tompkins, J. Hagen, A. A. Frazier, T. Lushnikova, M. P. Fitzgerald, A. di Tommaso, V. Ladeveze, F. E. Domann, C. M. Eischen, and D. E. Quelle A Novel Nuclear Interactor of ARF and MDM2 (NIAM) That Maintains Chromosomal Stability J. Biol. Chem., January 12, 2007; 282(2): 1322 - 1333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Rizos, H. A. McKenzie, A. L. Ayub, S. Woodruff, T. M. Becker, L. L. Scurr, J. Stahl, and R. F. Kefford Physical and Functional Interaction of the p14ARF Tumor Suppressor with Ribosomes J. Biol. Chem., December 8, 2006; 281(49): 38080 - 38088. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Enomoto, M. S. Lindstrom, A. Jin, H. Ke, and Y. Zhang Essential Role of the B23/NPM Core Domain in Regulating ARF Binding and B23 Stability J. Biol. Chem., July 7, 2006; 281(27): 18463 - 18472. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Alves da Costa, C. Sunyach, R. Pardossi-Piquard, J. Sevalle, B. Vincent, N. Boyer, T. Kawarai, N. Girardot, P. St. George-Hyslop, and F. Checler Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease. J. Neurosci., June 7, 2006; 26(23): 6377 - 6385. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Paliwal, S. Pande, R. C. Kovi, N. E. Sharpless, N. Bardeesy, and S. R. Grossman Targeting of C-Terminal Binding Protein (CtBP) by ARF Results in p53-Independent Apoptosis. Mol. Cell. Biol., March 1, 2006; 26(6): 2360 - 2372. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Lee, B. A. Smith, K. Bandyopadhyay, and R. A. Gjerset DNA Damage Disrupts the p14ARF-B23(Nucleophosmin) Interaction and Triggers a Transient Subnuclear Redistribution of p14ARF Cancer Res., November 1, 2005; 65(21): 9834 - 9842. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Colombo, P. Bonetti, E. Lazzerini Denchi, P. Martinelli, R. Zamponi, J.-C. Marine, K. Helin, B. Falini, and P. G. Pelicci Nucleophosmin Is Required for DNA Integrity and p19Arf Protein Stability Mol. Cell. Biol., October 15, 2005; 25(20): 8874 - 8886. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Datta, J. Sen, J. Hagen, C. K. Korgaonkar, M. Caffrey, D. E. Quelle, D. E. Hughes, T. J. Ackerson, R. H. Costa, and P. Raychaudhuri ARF Directly Binds DP1: Interaction with DP1 Coincides with the G1 Arrest Function of ARF Mol. Cell. Biol., September 15, 2005; 25(18): 8024 - 8036. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Yang, W. Khalaf, L. van de Locht, J. H. Jansen, M. Gao, M. A. Thompson, B. A. van der Reijden, D. H. Gutmann, R. Delwel, D. W. Clapp, et al. Transcriptional Repression of the Neurofibromatosis-1 Tumor Suppressor by the t(8;21) Fusion Protein Mol. Cell. Biol., July 15, 2005; 25(14): 5869 - 5879. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Kwong, L. H. Kalish, T. V. Nguyen, J. G. Kench, R. J. Bova, I. E. Cole, E. A. Musgrove, and R. L. Sutherland p14ARF Protein Expression Is a Predictor of Both Relapse and Survival in Squamous Cell Carcinoma of the Anterior Tongue Clin. Cancer Res., June 1, 2005; 11(11): 4107 - 4116. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Tago, S. Chiocca, and C. J. Sherr Sumoylation induced by the Arf tumor suppressor: A p53-independent function PNAS, May 24, 2005; 102(21): 7689 - 7694. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Meuwissen and A. Berns Mouse models for human lung cancer Genes & Dev., March 15, 2005; 19(6): 643 - 664. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Normand, P. G. Hemmati, B. Verdoodt, C. von Haefen, J. Wendt, D. Guner, E. May, B. Dorken, and P. T. Daniel p14ARF Induces G2 Cell Cycle Arrest in p53- and p21-deficient Cells by Down-regulating p34cdc2 Kinase Activity J. Biol. Chem., February 25, 2005; 280(8): 7118 - 7130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Korgaonkar, J. Hagen, V. Tompkins, A. A. Frazier, C. Allamargot, F. W. Quelle, and D. E. Quelle Nucleophosmin (B23) Targets ARF to Nucleoli and Inhibits Its Function Mol. Cell. Biol., February 15, 2005; 25(4): 1258 - 1271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. L. Woods, D. P. Xirodimas, A. R. Prescott, A. Sparks, D. P. Lane, and M. K. Saville p14 Arf Promotes Small Ubiquitin-like Modifier Conjugation of Werners Helicase J. Biol. Chem., November 26, 2004; 279(48): 50157 - 50166. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Calabro, G. Mansueto, R. Santoro, A. Gentilella, A. Pollice, P. Ghioni, L. Guerrini, and G. La Mantia Inhibition of p63 Transcriptional Activity by p14ARF: Functional and Physical Link between Human ARF Tumor Suppressor and a Member of the p53 Family Mol. Cell. Biol., October 1, 2004; 24(19): 8529 - 8540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Martin, J. D. Thornton, J. Liu, X. Wang, J. Zuo, M. M. Jablonski, E. Chaum, F. Zindy, and S. X. Skapek Pathogenesis of Persistent Hyperplastic Primary Vitreous in Mice Lacking the Arf Tumor Suppressor Gene Invest. Ophthalmol. Vis. Sci., October 1, 2004; 45(10): 3387 - 3396. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Datta, A. Nag, W. Pan, N. Hay, A. L. Gartel, O. Colamonici, Y. Mori, and P. Raychaudhuri Myc-ARF (Alternate Reading Frame) Interaction Inhibits the Functions of Myc J. Biol. Chem., August 27, 2004; 279(35): 36698 - 36707. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Carstens, A. Krempler, A. A. Triplett, M. van Lohuizen, and K.-U. Wagner Cell Cycle Arrest and Cell Death Are Controlled by p53-dependent and p53-independent Mechanisms in Tsg101-deficient Cells J. Biol. Chem., August 20, 2004; 279(34): 35984 - 35994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Magro, A. J. Russo, W.-W. Li, D. Banerjee, and J. R. Bertino p14ARF Expression Increases Dihydrofolate Reductase Degradation and Paradoxically Results in Resistance to Folate Antagonists in Cells with Nonfunctional p53 Cancer Res., June 15, 2004; 64(12): 4338 - 4345. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Yi, A. Shepard, F. Kittrell, B. Mulac-Jericevic, D. Medina, and T. K. Said p19ARF Determines the Balance between Normal Cell Proliferation Rate and Apoptosis during Mammary Gland Development Mol. Biol. Cell, May 1, 2004; 15(5): 2302 - 2311. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Sachs, N. E. Sharpless, R. A. DePinho, and N. Rosenberg p16Ink4a Interferes with Abelson Virus Transformation by Enhancing Apoptosis J. Virol., April 1, 2004; 78(7): 3304 - 3311. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pollice, V. Nasti, R. Ronca, M. Vivo, M. L. Iacono, R. Calogero, V. Calabro, and G. La Mantia Functional and Physical Interaction of the Human ARF Tumor Suppressor with Tat-binding Protein-1 J. Biol. Chem., February 20, 2004; 279(8): 6345 - 6353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Bertwistle, M. Sugimoto, and C. J. Sherr Physical and Functional Interactions of the Arf Tumor Suppressor Protein with Nucleophosmin/B23 Mol. Cell. Biol., February 1, 2004; 24(3): 985 - 996. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Zindy, R. T. Williams, T. A. Baudino, J. E. Rehg, S. X. Skapek, J. L. Cleveland, M. F. Roussel, and C. J. Sherr Arf tumor suppressor promoter monitors latent oncogenic signals in vivo PNAS, December 23, 2003; 100(26): 15930 - 15935. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Nakazawa, T. Kamijo, K. Koike, and T. Noda ARF Tumor Suppressor Induces Mitochondria-dependent Apoptosis by Modulation of Mitochondrial Bcl-2 Family Proteins J. Biol. Chem., July 18, 2003; 278(30): 27888 - 27895. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Huang, T. Tyler, N. Saadatmandi, C. Lee, P. Borgstrom, and R. A. Gjerset Enhanced Tumor Suppression by a p14ARF/p53 Bicistronic Adenovirus through Increased p53 Protein Translation and Stability Cancer Res., July 1, 2003; 63(13): 3646 - 3653. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Menendez, Z. Khan, D. W. Coomber, D. P. Lane, M. Higgins, M. M. Koufali, and S. Lain Oligomerization of the Human ARF Tumor Suppressor and Its Response to Oxidative Stress J. Biol. Chem., May 23, 2003; 278(21): 18720 - 18729. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Mitchell, E. Perez-Nadales, D. S. Malcolm, and A. C. Lloyd Dissecting the Contribution of p16INK4A and the Rb Family to the Ras Transformed Phenotype Mol. Cell. Biol., April 1, 2003; 23(7): 2530 - 2542. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-L. Kuo, E. J. Duncavage, R. Mathew, W. den Besten, D. Pei, D. Naeve, T. Yamamoto, C. Cheng, C. J. Sherr, and M. F. Roussel Arf Induces p53-dependent and -independent Antiproliferative Genes Cancer Res., March 1, 2003; 63(5): 1046 - 1053. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Rizos, E. Diefenbach, P. Badhwar, S. Woodruff, T. M. Becker, R. J. Rooney, and R. F. Kefford Association of p14ARF with the p120E4F Transcriptional Repressor Enhances Cell Cycle Inhibition J. Biol. Chem., February 7, 2003; 278(7): 4981 - 4989. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-I. Park, C. J. Strock, D. W. Ball, and B. D. Nelkin The Ras/Raf/MEK/Extracellular Signal-Regulated Kinase Pathway Induces Autocrine-Paracrine Growth Inhibition via the Leukemia Inhibitory Factor/JAK/STAT Pathway Mol. Cell. Biol., January 15, 2003; 23(2): 543 - 554. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Zhao, T. Samuels, S. Winckler, C. Korgaonkar, V. Tompkins, M. C. Horne, and D. E. Quelle Cyclin G1 Has Growth Inhibitory Activity Linked to the ARF-Mdm2-p53 and pRb Tumor Suppressor Pathways Mol. Cancer Res., January 1, 2003; 1(3): 195 - 206. [Abstract] [Full Text]
|
|
|
|
|
|
K. Y. Tsai, D. MacPherson, D. A. Rubinson, A. Yu. Nikitin, R. Bronson, K. L. Mercer, D. Crowley, and T. Jacks ARF mutation accelerates pituitary tumor development in Rb+/- mice PNAS, December 24, 2002; 99(26): 16865 - 16870. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Datta, A. Nag, and P. Raychaudhuri Differential Regulation of E2F1, DP1, and the E2F1/DP1 Complex by ARF Mol. Cell. Biol., December 15, 2002; 22(24): 8398 - 8408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. C. Day, M. T. McCabe, X. Zhao, Y. Wang, J. N. Davis, J. Phillips, M. Von Geldern, T. Ried, M. A. KuKuruga, G. R. Cunha, et al. Rescue of Embryonic Epithelium Reveals That the Homozygous Deletion of the Retinoblastoma Gene Confers Growth Factor Independence and Immortality but Does Not Influence Epithelial Differentiation or Tissue Morphogenesis J. Biol. Chem., November 8, 2002; 277(46): 44475 - 44484. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Wadhwa, T. Sugihara, Md. K. Hasan, K. Taira, R. R. Reddel, and S. C. Kaul A Major Functional Difference between the Mouse and Human ARF Tumor Suppressor Proteins J. Biol. Chem., September 20, 2002; 277(39): 36665 - 36670. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Eischen, J. E. Rehg, S. J. Korsmeyer, and J. L. Cleveland Loss of Bax Alters Tumor Spectrum and Tumor Numbers in ARF-deficient Mice Cancer Res., April 1, 2002; 62(7): 2184 - 2191. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Lewis, T. N. Truong, and M. A. Schwartz Integrins regulate the apoptotic response to DNA damage through modulation of p53 PNAS, March 19, 2002; 99(6): 3627 - 3632. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. N. McKeller, J. L. Fowler, J. J. Cunningham, N. Warner, R. J. Smeyne, F. Zindy, and S. X. Skapek The Arf tumor suppressor gene promotes hyaloid vascular regression during mouse eye development PNAS, March 19, 2002; 99(6): 3848 - 3853. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Russell, J. T. Powers, R. J. Rounbehler, P. M. Rogers, C. J. Conti, and D. G. Johnson ARF Differentially Modulates Apoptosis Induced by E2F1 and Myc Mol. Cell. Biol., March 1, 2002; 22(5): 1360 - 1368. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Lu, J. Lin, and J. Chen Expression of p14ARF Overcomes Tumor Resistance to p53 Cancer Res., March 1, 2002; 62(5): 1305 - 1310. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. M. Wood, V. D. Sarapura, J. M. Dowding, W. W. Woodmansee, D. J. Haakinson, D. F. Gordon, and E. C. Ridgway Early Gene Expression Changes Preceding Thyroid Hormone-Induced Involution of a Thyrotrope Tumor Endocrinology, February 1, 2002; 143(2): 347 - 359. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Korgaonkar, L. Zhao, M. Modestou, and D. E. Quelle ARF Function Does Not Require p53 Stabilization or Mdm2 Relocalization Mol. Cell. Biol., January 1, 2002; 22(1): 196 - 206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Tolbert, X. Lu, C. Yin, M. Tantama, and T. Van Dyke p19ARF Is Dispensable for Oncogenic Stress-Induced p53-Mediated Apoptosis and Tumor Suppression In Vivo Mol. Cell. Biol., January 1, 2002; 22(1): 370 - 377. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Eischen, M. F. Roussel, S. J. Korsmeyer, and J. L. Cleveland Bax Loss Impairs Myc-Induced Apoptosis and Circumvents the Selection of p53 Mutations during Myc-Mediated Lymphomagenesis Mol. Cell. Biol., November 15, 2001; 21(22): 7653 - 7662. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Chakravarti, M. A. Delaney, E. Noll, P. McL. Black, J. S. Loeffler, A. Muzikansky, and N. J. Dyson Prognostic and Pathologic Significance of Quantitative Protein Expression Profiling in Human Gliomas Clin. Cancer Res., August 1, 2001; 7(8): 2387 - 2395. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Nicholson, N. T. Okby, M. A. Khan, J. A. Welsh, M. G. McMenamin, W. D. Travis, J. R. Jett, H. D. Tazelaar, V. Trastek, P. C. Pairolero, et al. Alterations of p14ARF, p53, and p73 Genes Involved in the E2F-1-mediated Apoptotic Pathways in Non-Small Cell Lung Carcinoma Cancer Res., July 1, 2001; 61(14): 5636 - 5643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. W. Lin and S. W. Lowe Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation PNAS, April 12, 2001; (2001) 91100298. [Abstract] [Full Text]
|
|
|
|
|
|
M. Modestou, V. Puig-Antich, C. Korgaonkar, A. Eapen, and D. E. Quelle The Alternative Reading Frame Tumor Suppressor Inhibits Growth through p21-dependent and p21-independent Pathways Cancer Res., April 1, 2001; 61(7): 3145 - 3150. [Abstract] [Full Text]
|
|
|
|
|
|
F. Martelli, T. Hamilton, D. P. Silver, N. E. Sharpless, N. Bardeesy, M. Rokas, R. A. DePinho, D. M. Livingston, and S. R. Grossman p19ARF targets certain E2F species for degradation PNAS, March 22, 2001; (2001) 81061398. [Abstract] [Full Text]
|
|
|
|
|
|
M. Vivo, R. A. Caloger |
