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Vol. 14, No. 24, pp. 3087-3092, December 15, 2000
1 Department of Biological Sciences, Vanderbilt
University, and 2 Department of Cell Biology, Vanderbilt
University School of Medicine, Nashville, Tennessee 37235, USA
Spatial variations in the levels of bone morphogenetic protein
(BMP) signaling are a critical determinant of
dorsoanterior-ventroposterior pattern in vertebrate embryos. Whereas
BMP overexpression abolishes both head and trunk development, known
single and double loss-of-function mutations in BMP inhibitors have
less dramatic effects. We report that combining mutations in the
zebrafish genes bozozok and chordino causes a
synergistic loss of head and trunk, whereas most cells express
ventro-posterior markers and develop into a tail. Genetic inactivation
of BMP signaling fully suppresses these defects. Thus, a remarkably
simple genetic mechanism, involving a coinhibition of BMP function by
the partially overlapping bozozok and chordino pathways
is used to specify vertebrate head and trunk.
[Key Words: BMP signaling; zebrafish; bozozok; chordino]
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