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Vol. 14, No. 4, pp. 493-503, February 15, 2000
1 Department of Molecular and Cellular Biology, Harvard
University, Cambridge, Massachusetts 02138 USA; 2 Program
in Molecular Biology, Memorial Sloan-Kettering Cancer Center,
New York, New York USA 10021
Spo11p is a key mediator of interhomolog interactions during
meiosis. Deletion of the SPO11 gene decreases the length of S phase by ~25%. Rec8p is a key coordinator of meiotic interhomolog and intersister interactions. Deletion of the REC8 gene
increases S-phase length, by ~10% in wild-type and ~30% in a
spo11
background. Thus, the progression of DNA
replication is modulated by interchromosomal interaction proteins. The
spo11-Y135F DSB (double strand break) catalysis-defective
mutant is normal for S-phase modulation and DSB-independent homolog
pairing but is defective for later events, formation of DSBs, and
synaptonemal complexes. Thus, earlier and later functions of Spo11 are
defined. We propose that meiotic S-phase progression is linked directly
to development of specific chromosomal features required for meiotic
interhomolog interactions and that this feedback process is built upon
a more fundamental mechanism, common to all cell types, by which
S-phase progression is coupled to development of nascent intersister
connections and/or related aspects of chromosome
morphogenesis. Roles for Rec8 and/or Spo11 in progression
through other stages of meiosis are also revealed.
[Key Words: SPO11; REC8; DNA replication; meiosis]
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