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Vol. 15, No. 1, pp. 24-29, January 1, 2001
1 Department of Biochemistry and Molecular
Biology, The University of Texas M. D. Anderson Cancer Center,
Houston, Texas 77030, USA; 2 Center for Aging and
Developmental Biology, Box 645, University of Rochester, Rochester, New
York 14642, USA
math5 is a murine orthologue of atonal, a bHLH
proneural gene essential for the formation of photoreceptors and
chordotonal organs in Drosophila. The expression of
math5 coincides with the onset of retinal ganglion cell (RGC)
differentiation. Targeted deletion of math5 blocks the initial
differentiation of 80% of RGCs and results in an increase in
differentiated amacrine cells. Furthermore, the absence of
math5 abolishes the retinal expression of brn-3b and
the formation of virtually all brn-3b-expressing RGCs. These
results imply that math5 is a proneural gene essential for RGC
differentiation and that math5 acts upstream to activate brn-3b-dependent differentiation processes in RGCs.
[Key Words: bHLH; math5; POU-domain; brn-3b; retinal development]
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