![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 15, No. 10, pp. 1229-1241, May 15, 2001
National Institute of Child Health and Human Development, National
Institutes of Health, Bethesda, Maryland 20892-2753, USA;
1 Department of Biochemistry, University of Texas Southwestern
Medical Center, Dallas, Texas 75390-9038, USA
Mammals express four highly conserved TEAD/TEF transcription factors
that bind the same DNA sequence, but serve different functions during
development. TEAD-2/TEF-4 protein purified from mouse cells was
associated predominantly with a novel TEAD-binding domain at the amino
terminus of YAP65, a powerful transcriptional coactivator. YAP65
interacted specifically with the carboxyl terminus of all four TEAD
proteins. Both this interaction and sequence-specific DNA binding by
TEAD were required for transcriptional activation in mouse cells.
Expression of YAP in lymphocytic cells that normally do not support
TEAD-dependent transcription (e.g., MPC11) resulted in up to 300-fold
induction of TEAD activity. Conversely, TEAD overexpression squelched
YAP activity. Therefore, the carboxy-terminal acidic activation domain
in YAP is the transcriptional activation domain for TEAD transcription
factors. However, whereas TEAD was concentrated in the nucleus, excess
YAP65 accumulated in the cytoplasm as a complex with the cytoplasmic
localization protein, 14-3-3. Because TEAD-dependent transcription was
limited by YAP65, and YAP65 also binds Src/Yes protein tyrosine
kinases, we propose that YAP65 regulates TEAD-dependent transcription
in response to mitogenic signals.
[Key Words: TEAD; TEF; YAP; 14-3-3; transcription; Src]
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Sawada, H. Kiyonari, K. Ukita, N. Nishioka, Y. Imuta, and H. Sasaki Redundant Roles of Tead1 and Tead2 in Notochord Development and the Regulation of Cell Proliferation and Survival Mol. Cell. Biol., May 15, 2008; 28(10): 3177 - 3189. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Zhang, G. A. Smolen, and D. A. Haber Negative Regulation of YAP by LATS1 Underscores Evolutionary Conservation of the Drosophila Hippo Pathway Cancer Res., April 15, 2008; 68(8): 2789 - 2794. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Hao, A. Chun, K. Cheung, B. Rashidi, and X. Yang Tumor Suppressor LATS1 Is a Negative Regulator of Oncogene YAP J. Biol. Chem., February 29, 2008; 283(9): 5496 - 5509. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yoshida MCAT Elements and the TEF-1 Family of Transcription Factors in Muscle Development and Disease Arterioscler. Thromb. Vasc. Biol., January 1, 2008; 28(1): 8 - 17. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Zhao, X. Wei, W. Li, R. S. Udan, Q. Yang, J. Kim, J. Xie, T. Ikenoue, J. Yu, L. Li, et al. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control Genes & Dev., November 1, 2007; 21(21): 2747 - 2761. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Yagi, M. J. Kohn, I. Karavanova, K. J. Kaneko, D. Vullhorst, M. L. DePamphilis, and A. Buonanno Transcription factor TEAD4 specifies the trophectoderm lineage at the beginning of mammalian development Development, November 1, 2007; 134(21): 3827 - 3836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hucl, J. R. Brody, E. Gallmeier, C. A. Iacobuzio-Donahue, I. K. Farrance, and S. E. Kern High Cancer-Specific Expression of Mesothelin (MSLN) Is Attributable to an Upstream Enhancer Containing a Transcription Enhancer Factor Dependent MCAT Motif Cancer Res., October 1, 2007; 67(19): 9055 - 9065. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Pan Hippo signaling in organ size control Genes & Dev., April 15, 2007; 21(8): 886 - 897. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Garg, A. Srivastava, M. M. Davis, S. L. O'Keefe, L. Chow, and J. B. Bell Antagonizing Scalloped With a Novel Vestigial Construct Reveals an Important Role for Scalloped in Drosophila melanogaster Leg, Eye and Optic Lobe Development Genetics, February 1, 2007; 175(2): 659 - 669. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Anbanandam, D. C. Albarado, C. T. Nguyen, G. Halder, X. Gao, and S. Veeraraghavan Insights into transcription enhancer factor 1 (TEF-1) activity from the solution structure of the TEA domain PNAS, November 14, 2006; 103(46): 17225 - 17230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Pasquet, F. Naye, C. Faucheux, O. Bronchain, A. Chesneau, P. Thiebaud, and N. Theze Transcription Enhancer Factor-1-dependent Expression of the {alpha}-Tropomyosin Gene in the Three Muscle Cell Types J. Biol. Chem., November 10, 2006; 281(45): 34406 - 34420. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Dhananjayan, S. Ramamoorthy, O. Y. Khan, A. Ismail, J. Sun, J. Slingerland, B. W. O'Malley, and Z. Nawaz WW Domain Binding Protein-2, an E6-Associated Protein Interacting Protein, Acts as a Coactivator of Estrogen and Progesterone Receptors Mol. Endocrinol., October 1, 2006; 20(10): 2343 - 2354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Overholtzer, J. Zhang, G. A. Smolen, B. Muir, W. Li, D. C. Sgroi, C.-X. Deng, J. S. Brugge, and D. A. Haber Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon PNAS, August 15, 2006; 103(33): 12405 - 12410. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Radichev, S. W. Kwon, Y. Zhao, M. L. DePamphilis, and A. Vassilev Genetic Analysis of Human Orc2 Reveals Specific Domains That Are Required in Vivo for Assembly and Nuclear Localization of the Origin Recognition Complex J. Biol. Chem., August 11, 2006; 281(32): 23264 - 23273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Morin-Kensicki, B. N. Boone, M. Howell, J. R. Stonebraker, J. Teed, J. G. Alb, T. R. Magnuson, W. O'Neal, and S. L. Milgram Defects in Yolk Sac Vasculogenesis, Chorioallantoic Fusion, and Embryonic Axis Elongation in Mice with Targeted Disruption of Yap65 Mol. Cell. Biol., January 1, 2006; 26(1): 77 - 87. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sawada, Y. Nishizaki, H. Sato, Y. Yada, R. Nakayama, S. Yamamoto, N. Nishioka, H. Kondoh, and H. Sasaki Tead proteins activate the Foxa2 enhancer in the node in cooperation with a second factor Development, November 1, 2005; 132(21): 4719 - 4729. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. I. Aqeilan, V. Donati, A. Palamarchuk, F. Trapasso, M. Kaou, Y. Pekarsky, M. Sudol, and C. M. Croce WW Domain-Containing Proteins, WWOX and YAP, Compete for Interaction with ErbB-4 and Modulate Its Transcriptional Function Cancer Res., August 1, 2005; 65(15): 6764 - 6772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. V. Intine, M. Dundr, A. Vassilev, E. Schwartz, Y. Zhao, Y. Zhao, M. L. DePamphilis, and R. J. Maraia Nonphosphorylated Human La Antigen Interacts with Nucleolin at Nucleolar Sites Involved in rRNA Biogenesis Mol. Cell. Biol., December 15, 2004; 24(24): 10894 - 10904. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-H. Chen, S. J. Mullett, and A. F. R. Stewart Vgl-4, a Novel Member of the Vestigial-like Family of Transcription Cofactors, Regulates {alpha}1-Adrenergic Activation of Gene Expression in Cardiac Myocytes J. Biol. Chem., July 16, 2004; 279(29): 30800 - 30806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Howell, C. Borchers, and S. L. Milgram Heterogeneous Nuclear Ribonuclear Protein U Associates with YAP and Regulates Its Co-activation of Bax Transcription J. Biol. Chem., June 18, 2004; 279(25): 26300 - 26306. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Vigneault, S. McGraw, L. Massicotte, and M.-A. Sirard Transcription Factor Expression Patterns in Bovine In Vitro-Derived Embryos Priorto Maternal-Zygotic Transition Biol Reprod, June 1, 2004; 70(6): 1701 - 1709. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Fossdal, F. Jonasson, G. T. Kristjansdottir, A. Kong, H. Stefansson, S. Gosh, J. R. Gulcher, and K. Stefansson A novel TEAD1 mutation is the causative allele in Sveinsson's chorioretinal atrophy (helicoid peripapillary chorioretinal degeneration) Hum. Mol. Genet., May 1, 2004; 13(9): 975 - 981. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Stoeckman, L. Ma, and H. C. Towle Mlx Is the Functional Heteromeric Partner of the Carbohydrate Response Element-binding Protein in Glucose Regulation of Lipogenic Enzyme Genes J. Biol. Chem., April 9, 2004; 279(15): 15662 - 15669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Kaneko, T. Rein, Z.-S. Guo, K. Latham, and M. L. DePamphilis DNA Methylation May Restrict but Does Not Determine Differential Gene Expression at the Sgy/Tead2 Locus during Mouse Development Mol. Cell. Biol., March 1, 2004; 24(5): 1968 - 1982. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Milewski, N. C. Chi, J. Li, C. Brown, M. M. Lu, and J. A. Epstein Identification of minimal enhancer elements sufficient for Pax3 expression in neural crest and implication of Tead2 as a regulator of Pax3 Development, February 15, 2004; 131(4): 829 - 837. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Komuro, M. Nagai, N. E. Navin, and M. Sudol WW Domain-containing Protein YAP Associates with ErbB-4 and Acts as a Co-transcriptional Activator for the Carboxyl-terminal Fragment of ErbB-4 That Translocates to the Nucleus J. Biol. Chem., August 29, 2003; 278(35): 33334 - 33341. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Karasseva, G. Tsika, J. Ji, A. Zhang, X. Mao, and R. Tsika Transcription Enhancer Factor 1 Binds Multiple Muscle MEF2 and A/T-Rich Elements during Fast-to-Slow Skeletal Muscle Fiber Type Transitions Mol. Cell. Biol., August 1, 2003; 23(15): 5143 - 5164. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Leask, A. Holmes, C. M. Black, and D. J. Abraham Connective Tissue Growth Factor Gene Regulation. REQUIREMENTS FOR ITS INDUCTION BY TRANSFORMING GROWTH FACTOR-beta 2 IN FIBROBLASTS J. Biol. Chem., April 4, 2003; 278(15): 13008 - 13015. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Maeda, D. L. Chapman, and A. F. R. Stewart Mammalian Vestigial-like 2, a Cofactor of TEF-1 and MEF2 Transcription Factors That Promotes Skeletal Muscle Differentiation J. Biol. Chem., December 6, 2002; 277(50): 48889 - 48898. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Tomioka, M. Nishimoto, S. Miyagi, T. Katayanagi, N. Fukui, H. Niwa, M. Muramatsu, and A. Okuda Identification of Sox-2 regulatory region which is under the control of Oct-3/4-Sox-2 complex Nucleic Acids Res., July 15, 2002; 30(14): 3202 - 3213. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Zhou, H. Li, D. DeCamp, S. Chen, H. Shu, Y. Gong, M. Flaig, J. W. Gillespie, N. Hu, P. R. Taylor, et al. 2D Differential In-gel Electrophoresis for the Identification of Esophageal Scans Cell Cancer-specific Protein Markers Mol. Cell. Proteomics, February 1, 2002; 1(2): 117 - 123. [Abstract] [Full Text] [PDF]
|
|
