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Vol. 15, No. 11, pp. 1393-1405, June 1, 2001
Wellcome/CRC Institute and Department of Genetics, University of
Cambridge, Cambridge CB2 1QR, UK
The body axes of Drosophila are established during
oogenesis through reciprocal interactions between the germ line cells
and the somatic follicle cells that surround them. The Notch pathway is
required at two stages in this process: first, for the migration of the
follicle cells around the germ line cyst and, later, for the
polarization of the anterior-posterior (A-P) axis of the oocyte. Its
function in these events, however, has remained controversial. Using
clonal analysis, we show that Notch signaling controls cell proliferation and differentiation in the whole follicular epithelium. Notch mutant follicle cells remain in a precursor state and
fail to switch from the mitotic cell cycle to the endocycle.
Furthermore, removal of Delta from the germ line produces an identical
phenotype, showing that Delta signals from the germ cells to control
the timing of follicle cell differentiation. This explains the axis formation defects in Notch mutants, which arise because
undifferentiated posterior follicle cells cannot signal to polarize the
oocyte. Delta also signals from the germ line to Notch in the soma
earlier in oogenesis to control the differentiation of the polar and
stalk follicle cells. The germ line therefore regulates the development of the follicle cells through two complementary signaling pathways: Gurken signals twice to control spatial patterning, whereas Delta signals twice to exert temporal control.
[Key Words: Germ line; oogenesis; cell cycle]
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