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Vol. 15, No. 12, pp. 1487-1492, June 15, 2001
1 Institut de Génétique et de Biologie Moléculaire
et Cellulaire, CNRS/INSERM/ULP, F-67404 Illkirch Cedex, C.U. de
Strasbourg, France; 2 U 368 INSERM, Ecole Normale
Supérieure, F-75230 PARIS CEDEX 05, France; 3 Max Planck
Institut fuer Molekulare Genetik, D-14195 Berlin (Dahlem), Germany
casanova (cas) mutant zebrafish embryos
lack endoderm and develop cardia bifida. In a substractive screen for
Nodal-responsive genes, we isolated an HMG box-containing gene,
10J3, which is expressed in the endoderm. The
cas phenotype is rescued by overexpression of 10J3
and can be mimicked by 10J3-directed morpholinos.
Furthermore, we identified a mutation within 10J3 coding
sequence that cosegregates with the cas phenotype, clearly
demonstrating that cas is encoded by 10J3.
Epistasis experiments are consistent with an instructive role for
cas in endoderm formation downstream of Nodal signals and
upstream of sox17. In the absence of cas
activity, endoderm progenitors differentiate into mesodermal
derivatives. Thus, cas is an HMG box-containing gene
involved in the fate decision between endoderm and mesoderm that acts
downstream of Nodal signals.
[Key Words: casanova; endoderm; nodal; cloning; zebrafish; sox]
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