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Vol. 15, No. 13, pp. 1631-1636, July 1, 2001
1 The Walter and Eliza Hall Institute of Medical
Research, Bone Marrow Research Laboratories, and 2 Cooperative
Research Centre for Cellular Growth Factors, PO Royal Melbourne
Hospital, VIC 3050, Australia; 3 Garvan Institute of Medical
Research, Darlinghurst, NSW 2010, Australia
Prolactin is essential for proliferation and differentiation of
the developing mammary gland. We have explored a role for Suppressor of
Cytokine Signaling 1 (SOCS1) as a modulator of the prolactin response
using mice deficient in SOCS1, which were rescued from neonatal death
by deletion of the Interferon gamma (IFN
) gene.
SOCS1
//IFN/ mice exhibited
accelerated lobuloalveolar development in the mammary gland during late
pregnancy and precocious lactation. Significantly, the lactogenic
defect in prolactin receptor heterozygous females could be rescued by
deletion of a single SOCS1 allele. These findings establish a
role for SOCS1 as a negative regulator of prolactin signaling and suggest that
SOCS1 is required for the prevention of lactation prior to parturition.
[Key Words: Prolactin receptor; SOCS1; mammary gland]
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