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Vol. 15, No. 13, pp. 1716-1723, July 1, 2001
1 Biozentrum, University of Basel, CH-4056 Basel,
Switzerland; 2 Graduate School of Pharmaceutical Science,
Tohoku University, Aramaki Aoba-ku, Sendai 980-8578, Japan
Pax-6 genes, known to be essential for eye development,
encode an evolutionarily conserved transcription factor with two
DNA-binding domains. To corroborate the contribution of each
DNA-binding domain to eye formation, we generated truncated forms of
the Drosophila Pax-6 gene eyeless and tested their
capacity to rescue the ey2 mutant. Surprisingly, EY
deleted of the homeodomain rescued the ey2 mutant and
triggered ectopic eyes morphogenesis. In contrast, EY lacking the
paired domain failed to rescue the ey2 mutant, led to
truncation of appendages, and repressed Distal-less when
misexpressed. This result suggests distinct functions mediated differentially by the two DNA-binding domains of eyeless.
[Key Words: eyeless; Pax-6; eye development; paired domain; homeodomain]
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