.gif?ad=16839&adview=true)
![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 15, No. 16, pp. 2069-2082, August 15, 2001
Department of Oncology, DNAX Research Institute,
Palo Alto, California 94304, USA
The Myc protein binds DNA and activates transcription by mechanisms
that are still unclear. We used chromatin immunoprecipitation (ChIP) to
evaluate Myc-dependent changes in histone acetylation at seven target
loci. Upon serum stimulation of Rat1 fibroblasts, Myc associated with
chromatin, histone H4 became locally hyperacetylated, and gene
expression was induced. These responses were lost or severely impaired
in Myc-deficient cells, but were restored by adenoviral delivery of Myc
simultaneous with mitogenic stimulation. When targeted to chromatin in
the absence of mitogens, Myc directly induced H4 acetylation. In
addition, Myc recruited TRRAP to chromatin, consistent with a role for
this cofactor in histone acetylation. Finally, unlike serum, Myc alone
was very inefficient in inducing expression of most target genes. Myc
therefore governs a step, most likely H4 acetylation, that is required
but not sufficient for transcriptional activation. We propose that Myc
acts as a permissive factor, allowing additional signals to activate
target promoters.
[Key Words: Chromatin; histone acetylation; Myc; TRRAP; HAT; nucleolin]
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  Q. Gan, J. Huang, R. Zhou, J. Niu, X. Zhu, J. Wang, Z. Zhang, and T. Tong PPAR{gamma} accelerates cellular senescence by inducing p16INK4{alpha} expression in human diploid fibroblasts J. Cell Sci., July 1, 2008; 121(13): 2235 - 2245. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Della Gatta, M. Bansal, A. Ambesi-Impiombato, D. Antonini, C. Missero, and D. di Bernardo Direct targets of the TRP63 transcription factor revealed by a combination of gene expression profiling and reverse engineering Genome Res., June 1, 2008; 18(6): 939 - 948. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Labalette, Y. Nouet, J. Sobczak-Thepot, C. Armengol, F. Levillayer, M.-C. Gendron, C.-A. Renard, B. Regnault, J. Chen, M.-A. Buendia, et al. The LIM-only Protein FHL2 Regulates Cyclin D1 Expression and Cell Proliferation J. Biol. Chem., May 30, 2008; 283(22): 15201 - 15208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. Kurland and W. P. Tansey Myc-Mediated Transcriptional Repression by Recruitment of Histone Deacetylase Cancer Res., May 15, 2008; 68(10): 3624 - 3629. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Unni, T. Bondar, and R. Medzhitov Intrinsic sensor of oncogenic transformation induces a signal for innate immunosurveillance PNAS, February 5, 2008; 105(5): 1686 - 1691. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Vaque, B. Fernandez-Garcia, P. Garcia-Sanz, N. Ferrandiz, G. Bretones, F. Calvo, P. Crespo, M. C. Marin, and J. Leon c-Myc Inhibits Ras-Mediated Differentiation of Pheochromocytoma Cells by Blocking c-Jun Up-Regulation Mol. Cancer Res., February 1, 2008; 6(2): 325 - 339. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Liu, M. Vorontchikhina, Y.-L. Wang, F. Faiola, and E. Martinez STAGA Recruits Mediator to the MYC Oncoprotein To Stimulate Transcription and Cell Proliferation Mol. Cell. Biol., January 1, 2008; 28(1): 108 - 121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Dirlam, B. T. Spike, and K. F. Macleod Deregulated E2f-2 Underlies Cell Cycle and Maturation Defects in Retinoblastoma Null Erythroblasts Mol. Cell. Biol., December 15, 2007; 27(24): 8713 - 8728. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. S. Kenneth, B. A. Ramsbottom, N. Gomez-Roman, L. Marshall, P. A. Cole, and R. J. White TRRAP and GCN5 are used by c-Myc to activate RNA polymerase III transcription PNAS, September 18, 2007; 104(38): 14917 - 14922. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-H. Wu, J. van Riggelen, A. Yetil, A. C. Fan, P. Bachireddy, and D. W. Felsher Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation PNAS, August 7, 2007; 104(32): 13028 - 13033. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Jason Collier, P. Zhang, K. B. Pedersen, S. J. Burke, J. W. Haycock, and D. K. Scott c-Myc and ChREBP regulate glucose-mediated expression of the L-type pyruvate kinase gene in INS-1-derived 832/13 cells Am J Physiol Endocrinol Metab, July 1, 2007; 293(1): E48 - E56. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. D. Zhang, A. Paccanaro, Y. Fu, S. Weissman, Z. Weng, J. Chang, M. Snyder, and M. B. Gerstein Statistical analysis of the genomic distribution and correlation of regulatory elements in the ENCODE regions Genome Res., June 1, 2007; 17(6): 787 - 797. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Lefort, A. Mandinova, P. Ostano, V. Kolev, V. Calpini, I. Kolfschoten, V. Devgan, J. Lieb, W. Raffoul, D. Hohl, et al. Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCK{alpha} kinases Genes & Dev., March 1, 2007; 21(5): 562 - 577. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Secombe, L. Li, L. Carlos, and R. N. Eisenman The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth Genes & Dev., March 1, 2007; 21(5): 537 - 551. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Lemasson, M. R. Lewis, N. Polakowski, P. Hivin, M.-H. Cavanagh, S. Thebault, B. Barbeau, J. K. Nyborg, and J.-M. Mesnard Human T-Cell Leukemia Virus Type 1 (HTLV-1) bZIP Protein Interacts with the Cellular Transcription Factor CREB To Inhibit HTLV-1 Transcription J. Virol., February 15, 2007; 81(4): 1543 - 1553. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Cayrol, C. Lacroix, C. Mathe, V. Ecochard, M. Ceribelli, E. Loreau, V. Lazar, P. Dessen, R. Mantovani, L. Aguilar, et al. The THAP-zinc finger protein THAP1 regulates endothelial cell proliferation through modulation of pRB/E2F cell-cycle target genes Blood, January 15, 2007; 109(2): 584 - 594. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Benhamed, C. Bertrand, C. Servet, and D.-X. Zhou Arabidopsis GCN5, HD1, and TAF1/HAF2 Interact to Regulate Histone Acetylation Required for Light-Responsive Gene Expression PLANT CELL, November 1, 2006; 18(11): 2893 - 2903. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. E. MacConaill, C. M. Hughes, O. Rozenblatt-Rosen, S. Nannepaga, and M. Meyerson Phosphorylation of the Menin Tumor Suppressor Protein on Serine 543 and Serine 583 Mol. Cancer Res., October 1, 2006; 4(10): 793 - 801. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. H. Cowling, S. Chandriani, M. L. Whitfield, and M. D. Cole A Conserved Myc Protein Domain, MBIV, Regulates DNA Binding, Apoptosis, Transformation, and G2 Arrest. Mol. Cell. Biol., June 1, 2006; 26(11): 4226 - 4239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Lemasson, N. J. Polakowski, P. J. Laybourn, and J. K. Nyborg Tax-dependent Displacement of Nucleosomes during Transcriptional Activation of Human T-Cell Leukemia Virus Type 1 J. Biol. Chem., May 12, 2006; 281(19): 13075 - 13082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Antonini, B. Rossi, R. Han, A. Minichiello, T. Di Palma, M. Corrado, S. Banfi, M. Zannini, J. L. Brissette, and C. Missero An Autoregulatory Loop Directs the Tissue-Specific Expression of p63 through a Long-Range Evolutionarily Conserved Enhancer Mol. Cell. Biol., April 15, 2006; 26(8): 3308 - 3318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B.-C. Nguyen, K. Lefort, A. Mandinova, D. Antonini, V. Devgan, G. Della Gatta, M. I. Koster, Z. Zhang, J. Wang, A. T. di Vignano, et al. Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation Genes & Dev., April 15, 2006; 20(8): 1028 - 1042. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Jackson and O. M. Pereira-Smith Primary and Compensatory Roles for RB Family Members at Cell Cycle Gene Promoters That Are Deacetylated and Downregulated in Doxorubicin-Induced Senescence of Breast Cancer Cells. Mol. Cell. Biol., April 1, 2006; 26(7): 2501 - 2510. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Guney, S. Wu, and J. M. Sedivy Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16INK4a. PNAS, March 7, 2006; 103(10): 3645 - 3650. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Prathapam, S. Tegen, T. Oskarsson, A. Trumpp, and G. S. Martin Activated Src abrogates the Myc requirement for the G0/G1 transition but not for the G1/S transition PNAS, February 21, 2006; 103(8): 2695 - 2700. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Shiio, K. S. Suh, H. Lee, S. H. Yuspa, R. N. Eisenman, and R. Aebersold Quantitative Proteomic Analysis of Myc-induced Apoptosis: A DIRECT ROLE FOR Myc INDUCTION OF THE MITOCHONDRIAL CHLORIDE ION CHANNEL, mtCLIC/CLIC4 J. Biol. Chem., February 3, 2006; 281(5): 2750 - 2756. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Villa, L. Morey, V. A. Raker, M. Buschbeck, A. Gutierrez, F. De Santis, M. Corsaro, F. Varas, D. Bossi, S. Minucci, et al. The methyl-CpG binding protein MBD1 is required for PML-RAR{alpha} function PNAS, January 31, 2006; 103(5): 1400 - 1405. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Milne, M. E. Martin, H. W. Brock, R. K. Slany, and J. L. Hess Leukemogenic MLL Fusion Proteins Bind across a Broad Region of the Hox a9 Locus, Promoting Transcription and Multiple Histone Modifications Cancer Res., December 15, 2005; 65(24): 11367 - 11374. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Faiola, X. Liu, S. Lo, S. Pan, K. Zhang, E. Lymar, A. Farina, and E. Martinez Dual Regulation of c-Myc by p300 via Acetylation-Dependent Control of Myc Protein Turnover and Coactivation of Myc-Induced Transcription Mol. Cell. Biol., December 1, 2005; 25(23): 10220 - 10234. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Dentice, C. Luongo, A. Elefante, R. Ambrosio, S. Salzano, M. Zannini, R. Nitsch, R. Di Lauro, G. Rossi, G. Fenzi, et al. Pendrin Is a Novel In Vivo Downstream Target Gene of the TTF-1/Nkx-2.1 Homeodomain Transcription Factor in Differentiated Thyroid Cells Mol. Cell. Biol., November 15, 2005; 25(22): 10171 - 10182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Wang, R. A. Baiocchi, S. Pal, G. Mosialos, M. Caligiuri, and S. Sif The BRG1- and hBRM-Associated Factor BAF57 Induces Apoptosis by Stimulating Expression of the Cylindromatosis Tumor Suppressor Gene Mol. Cell. Biol., September 15, 2005; 25(18): 7953 - 7965. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Perini, D. Diolaiti, A. Porro, and G. Della Valle In vivo transcriptional regulation of N-Myc target genes is controlled by E-box methylation PNAS, August 23, 2005; 102(34): 12117 - 12122. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Olsen, S. Bressendorff, J. T. Troelsen, and J. Olsen Differentiation-dependent activation of the human intestinal alkaline phosphatase promoter by HNF-4 in intestinal cells Am J Physiol Gastrointest Liver Physiol, August 1, 2005; 289(2): G220 - G226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Hirayama, L. Cardone, M. Doi, and P. Sassone-Corsi Common pathways in circadian and cell cycle clocks: Light-dependent activation of Fos/AP-1 in zebrafish controls CRY-1a and WEE-1 PNAS, July 19, 2005; 102(29): 10194 - 10199. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Brendolan, E. Ferretti, V. Salsi, K. Moses, S. Quaggin, F. Blasi, M. L. Cleary, and L. Selleri A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny Development, July 1, 2005; 132(13): 3113 - 3126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hulf, P. Bellosta, M. Furrer, D. Steiger, D. Svensson, A. Barbour, and P. Gallant Whole-Genome Analysis Reveals a Strong Positional Bias of Conserved dMyc-Dependent E-Boxes Mol. Cell. Biol., May 1, 2005; 25(9): 3401 - 3410. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Tominaga, B. Kirtane, J. G. Jackson, Y. Ikeno, T. Ikeda, C. Hawks, J. R. Smith, M. M. Matzuk, and O. M. Pereira-Smith MRG15 Regulates Embryonic Development and Cell Proliferation Mol. Cell. Biol., April 15, 2005; 25(8): 2924 - 2937. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. Denchi, C. Attwooll, D. Pasini, and K. Helin Deregulated E2F Activity Induces Hyperplasia and Senescence-Like Features in the Mouse Pituitary Gland Mol. Cell. Biol., April 1, 2005; 25(7): 2660 - 2672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Fujii-Yamamoto, J. M. Kim, K.-i. Arai, and H. Masai Cell Cycle and Developmental Regulations of Replication Factors in Mouse Embryonic Stem Cells J. Biol. Chem., April 1, 2005; 280(13): 12976 - 12987. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. M. Chan, M. Narita, S. W. Lowe, and D. M. Livingston The p400 E1A-associated protein is a novel component of the p53 -> p21 senescence pathway Genes & Dev., January 15, 2005; 19(2): 196 - 201. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Liu, L. Li, J. N. Rao, T. Zou, H. M. Zhang, D. Boneva, M. S. Bernard, and J.-Y. Wang Polyamine-modulated expression of c-myc plays a critical role in stimulation of normal intestinal epithelial cell proliferation Am J Physiol Cell Physiol, January 1, 2005; 288(1): C89 - C99. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Patel, Y. Du, P. G. Ard, C. Phillips, B. Carella, C.-J. Chen, C. Rakowski, C. Chatterjee, P. M. Lieberman, W. S. Lane, et al. The c-MYC Oncoprotein Is a Substrate of the Acetyltransferases hGCN5/PCAF and TIP60 Mol. Cell. Biol., December 15, 2004; 24(24): 10826 - 10834. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Galceran, C. Sustmann, S.-C. Hsu, S. Folberth, and R. Grosschedl LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis Genes & Dev., November 15, 2004; 18(22): 2718 - 2723. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Wilson, M. J. Murphy, T. Oskarsson, K. Kaloulis, M. D. Bettess, G. M. Oser, A.-C. Pasche, C. Knabenhans, H. R. MacDonald, and A. Trumpp c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation Genes & Dev., November 15, 2004; 18(22): 2747 - 2763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Demma, S. Wong, E. Maxwell, and B. Dasmahapatra CP-31398 Restores DNA-binding Activity to Mutant p53 in Vitro but Does Not Affect p53 Homologs p63 and p73 J. Biol. Chem., October 29, 2004; 279(44): 45887 - 45896. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Lemasson, N. J. Polakowski, P. J. Laybourn, and J. K. Nyborg Transcription Regulatory Complexes Bind the Human T-Cell Leukemia Virus 5' and 3' Long Terminal Repeats To Control Gene Expression Mol. Cell. Biol., July 15, 2004; 24(14): 6117 - 6126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Ling, C. R. Hauer, R. M. Gronostajski, B. T. Pentecost, and X. Ding Transcriptional Regulation of Rat CYP2A3 by Nuclear Factor 1: IDENTIFICATION OF A NOVEL NFI-A ISOFORM, AND EVIDENCE FOR TISSUE-SELECTIVE INTERACTION OF NFI WITH THE CYP2A3 PROMOTER IN VIVO J. Biol. Chem., July 2, 2004; 279(27): 27888 - 27895. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Y. L. Mao, D. Barsyte-Lovejoy, C. S. W. Ho, J. D. Watson, A. Stojanova, and L. Z. Penn Promoter-binding and repression of PDGFRB by c-Myc are separable activities Nucleic Acids Res., June 29, 2004; 32(11): 3462 - 3468. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Amati Myc degradation: Dancing with ubiquitin ligases PNAS, June 15, 2004; 101(24): 8843 - 8844. [Full Text] [PDF]
|
|
|
|
|
|
S. Taubert, C. Gorrini, S. R. Frank, T. Parisi, M. Fuchs, H.-M. Chan, D. M. Livingston, and B. Amati E2F-Dependent Histone Acetylation and Recruitment of the Tip60 Acetyltransferase Complex to Chromatin in Late G1 Mol. Cell. Biol., May 15, 2004; 24(10): 4546 - 4556. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-C. Teng, Y.-Y. Chen, Y.-N. Su, P.-C. Chou, Y.-C. Chiang, S.-F. Tseng, and K.-J. Wu Direct Activation of HSP90A Transcription by c-Myc Contributes to c-Myc-induced Transformation J. Biol. Chem., April 9, 2004; 279(15): 14649 - 14655. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Nilsson, K. H. Maclean, U. B. Keller, H. Pendeville, T. A. Baudino, and J. L. Cleveland Mnt Loss Triggers Myc Transcription Targets, Proliferation, Apoptosis, and Transformation Mol. Cell. Biol., February 15, 2004; 24(4): 1560 - 1569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Greenwald, J. R. Tumang, A. Sinha, N. Currier, R. D. Cardiff, T. L. Rothstein, D. V. Faller, and G. V. Denis E{micro}-BRD2 transgenic mice develop B-cell lymphoma and leukemia Blood, February 15, 2004; 103(4): 1475 - 1484. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Herceg, H. Li, C. Cuenin, V. Shukla, M. Radolf, P. Steinlein, and Z.-Q. Wang Genome-wide analysis of gene expression regulated by the HAT cofactor Trrap in conditional knockout cells Nucleic Acids Res., December 1, 2003; 31(23): 7011 - 7023. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Adhikary, K. Peukert, H. Karsunky, V. Beuger, W. Lutz, H.-P. Elsasser, T. Moroy, and M. Eilers Miz1 Is Required for Early Embryonic Development during Gastrulation Mol. Cell. Biol., November 1, 2003; 23(21): 7648 - 7657. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Hadsell, S. Bonnette, J. George, D. Torres, Y. Klementidis, S. Gao, P. M. Haney, J. Summy-Long, M. S. Soloff, A. F. Parlow, et al. Diminished Milk Synthesis in Upstream Stimulatory Factor 2 Null Mice Is Associated With Decreased Circulating Oxytocin and Decreased Mammary Gland Expression of Eukaryotic Initiation Factors 4E and 4G Mol. Endocrinol., November 1, 2003; 17(11): 2251 - 2267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Caretti, V. Salsi, C. Vecchi, C. Imbriano, and R. Mantovani Dynamic Recruitment of NF-Y and Histone Acetyltransferases on Cell-cycle Promoters J. Biol. Chem., August 15, 2003; 278(33): 30435 - 30440. [Abstract] [Full Text] [PDF]
|
|
|
|
