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Vol. 15, No. 17, pp. 2209-2214, September 1, 2001
1 Department of Zoology and Animal Biology,
University of Geneva, Sciences III, 1211 Geneva 4, Switzerland;
2 Department of Molecular Biology, Princeton University,
Princeton, New Jersey 08544, USA
The ancestral role of the Hox gene family is specifying
morphogenetic differences along the main body axis. In vertebrates, HoxD genes were also co-opted along with the emergence of novel structures such as limbs and genitalia. We propose that these functional recruitments relied on the appearance, or implementation, of
regulatory sequences outside of the complex. Whereas transgenic human
and murine HOXD clusters could function during axial patterning, in
mice they were not expressed outside the trunk. Accordingly, deletion
of the entire cluster abolished axial expression, whereas recently
acquired regulatory controls were preserved.
[Key Words: Hox cluster; colinearity; BAC; remote enhancers]
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