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Vol. 15, No. 19, pp. 2509-2514, October 1, 2001
Department of Zoology, University of Geneva, CH-1211 Geneva, Switzerland
Two distinct types of Polycomb complexes have been identified in
flies and in vertebrates, one containing ESC and one containing PC.
Using LexA fusions, we show that PC and ESC can establish silencing of
a reporter gene but that each requires the presence of the other. In
early embryonic extracts, we find PC transiently associated with ESC in
a complex that includes EZ, PHO, PH, GAGA, and RPD3 but not PSC. In
older embryos, PC is found in a complex including PH, PSC, GAGA, and
RPD3, whereas ESC is in a separate complex including EZ, PHO, and RPD3.
[Key Words: Polycomb silencing; ESC/PHO; PcG complex]
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